THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS

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VAFAEE FARZANEH; HOSSEINI MAHMOUD; HASSANZADEH ZAHRA; EDALATMANESH MOHAMMAD AMIN; SADEGHNIA HAMID REZA; SEGHATOLESLAM MASOUMEH; MOUSAVI SEYED MOJTABA; AMANI ATEFEH; SHAFEI MOHAMMAD NASER

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 547-557

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Title

THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS

Author(s)

Keywords

Nigella sativa

Pentylenetetrazole

Repeated seizures

Oxidative stress

Memory

Abstract

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, Memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ)-induced Repeated seizures. There were 4 experimental groups including: 1-control group; received saline, 2-PTZ group; received saline and PTZ (50 mg/Kg, i. p), 3-PTZ-NS 200 and 4-PTZ-NS 400; received 200 and 400 mg/Kg of NS extract respectively, before PTZ injection in 5 consecutive days. Seizure scores were lower in PTZ – NS 200 and 400, furthermore the seizure onset latencies were higher in these groups than PTZ group (P<0. 05 and P<0. 01 ). In Morris water maze, the time spent in target quadrant by PTZ group was lower than control group (P<0. 05); while, 400 mg/Kg of the extract increased it (P<0. 01). In the passive avoidance test, delay time to enter the dark by PTZ group was lower than control at 1 and 24 hours after training (P<0. 01-P<0. 001); while, 400 mg/Kg of the extract increased it (P<0. 05). The total thiol concentration in hippocampal and cortical tissues of PTZ group was reduced while, MDA concentration was higher than control (p<0. 05-p<0. 001). Administration of the extract increased the total thiol and decreased the MDA concentrations (p<0. 01-p<0. 001). It is concluded that the hydro-alcoholic extract of NS possess beneficial effects on learning and Memory impairments in Repeated seizures model which is accompanied by antioxidant effects in the brain.

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