THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS

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VAFAEE FARZANEH; HOSSEINI MAHMOUD; HASSANZADEH ZAHRA; EDALATMANESH MOHAMMAD AMIN; SADEGHNIA HAMID REZA; SEGHATOLESLAM MASOUMEH; MOUSAVI SEYED MOJTABA; AMANI ATEFEH; SHAFEI MOHAMMAD NASER

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 547-557

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Title

THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS

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Keywords

Nigella sativa

Pentylenetetrazole

Repeated seizures

Oxidative stress

Memory

Abstract

Regarding the therapeutic properties of Nigella sativa (NS), the effects of the plant hydro – alcoholic extract on learning, Memory and brain tissues oxidative damage were investigated in penthylenetetrazole (PTZ)-induced Repeated seizures. There were 4 experimental groups including: 1-control group; received saline, 2-PTZ group; received saline and PTZ (50 mg/Kg, i. p), 3-PTZ-NS 200 and 4-PTZ-NS 400; received 200 and 400 mg/Kg of NS extract respectively, before PTZ injection in 5 consecutive days. Seizure scores were lower in PTZ – NS 200 and 400, furthermore the seizure onset latencies were higher in these groups than PTZ group (P<0. 05 and P<0. 01 ). In Morris water maze, the time spent in target quadrant by PTZ group was lower than control group (P<0. 05); while, 400 mg/Kg of the extract increased it (P<0. 01). In the passive avoidance test, delay time to enter the dark by PTZ group was lower than control at 1 and 24 hours after training (P<0. 01-P<0. 001); while, 400 mg/Kg of the extract increased it (P<0. 05). The total thiol concentration in hippocampal and cortical tissues of PTZ group was reduced while, MDA concentration was higher than control (p<0. 05-p<0. 001). Administration of the extract increased the total thiol and decreased the MDA concentrations (p<0. 01-p<0. 001). It is concluded that the hydro-alcoholic extract of NS possess beneficial effects on learning and Memory impairments in Repeated seizures model which is accompanied by antioxidant effects in the brain.

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APA: Copy

VAFAEE, FARZANEH, HOSSEINI, MAHMOUD, HASSANZADEH, ZAHRA, EDALATMANESH, MOHAMMAD AMIN, SADEGHNIA, HAMID REZA, SEGHATOLESLAM, MASOUMEH, MOUSAVI, SEYED MOJTABA, AMANI, ATEFEH, & SHAFEI, MOHAMMAD NASER. (2015). THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 547-557. SID. https://sid.ir/paper/288470/en

Vancouver: Copy

VAFAEE FARZANEH, HOSSEINI MAHMOUD, HASSANZADEH ZAHRA, EDALATMANESH MOHAMMAD AMIN, SADEGHNIA HAMID REZA, SEGHATOLESLAM MASOUMEH, MOUSAVI SEYED MOJTABA, AMANI ATEFEH, SHAFEI MOHAMMAD NASER. THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):547-557. Available from: https://sid.ir/paper/288470/en

IEEE: Copy

FARZANEH VAFAEE, MAHMOUD HOSSEINI, ZAHRA HASSANZADEH, MOHAMMAD AMIN EDALATMANESH, HAMID REZA SADEGHNIA, MASOUMEH SEGHATOLESLAM, SEYED MOJTABA MOUSAVI, ATEFEH AMANI, and MOHAMMAD NASER SHAFEI, “THE EFFECTS OF NIGELLA SATIVA HYDRO-ALCOHOLIC EXTRACT ON MEMORY AND BRAIN TISSUES OXIDATIVE DAMAGE AFTER REPEATED SEIZURES IN RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 547–557, 2015, [Online]. Available: https://sid.ir/paper/288470/en

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