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Information Journal Paper

Title

Ethanol and Cancer Induce Similar Changes on Protein Expression Pattern of Human Fibroblast Cell

Pages

  175-184

Keywords

Human Foreskin Fibroblast cell line (HFFF2) 
Protein-protein Interaction (PPIs) 

Abstract

 Ethanol has a vast consumption around the world. Many researches confirmed some adverse effect of this component on human health. In addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (HFFF2) in the specific dosage of Ethanol. Here, the role and interaction of some proteins (characterized by significant alteration in expression due to Ethanol effect) analyzed by Proteomics and evaluated by considering cancerous case. 2D-electrophoresis findings of comparison of normal fibroblast cells and treated fibroblast with 270 mM dosage of Ethanol analyzed by using SameSpots software, R software, and Cytoscape for protein-protein interaction (PPI) investigation. Six proteins with significantly altered expression associated with fundamental properties in a cell identified in Ethanol-treated sample. These include AnnexinA5, Heterogeneous nuclear ribonucleoprotein A1, Rho-GDP dissociation inhibitor, Cathepsin L, Cu/Zn-SOD, Rho-GDP dissociation inhibitor, and Serpin peptidase inhibitor. Surprisingly, all these proteins were down-regulated and this pattern is similar to nasopharyngeal carcinoma-associated stromal fibroblast sample. Additionally, protein-protein interaction (PPI) indicates that HNRNPA1, SERPINE1 are hub proteins. Once their expression alters, it can impose vast changes on other molecular function. Based on this approach, Ethanol may target same pathways that are related to cancer onset. In addition, some epidemiologic studies proved that Ethanol consumption is related to increment of cancer risk. Therefore, more investigation is required in this regard to elicit the feasible relationship.

Cites

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    • Cite

    APA: Copy

    ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, RAHMATIRAD, SARA, & REZAEI TAVIRANI, MAJID. (2016). Ethanol and Cancer Induce Similar Changes on Protein Expression Pattern of Human Fibroblast Cell. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(Special issue), 175-184. SID. https://sid.ir/paper/288600/en

    Vancouver: Copy

    ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, RAHMATIRAD SARA, REZAEI TAVIRANI MAJID. Ethanol and Cancer Induce Similar Changes on Protein Expression Pattern of Human Fibroblast Cell. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(Special issue):175-184. Available from: https://sid.ir/paper/288600/en

    IEEE: Copy

    MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, SARA RAHMATIRAD, and MAJID REZAEI TAVIRANI, “Ethanol and Cancer Induce Similar Changes on Protein Expression Pattern of Human Fibroblast Cell,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. Special issue, pp. 175–184, 2016, [Online]. Available: https://sid.ir/paper/288600/en

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