PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF HUMAN FIBROBLAST CELLS TREATED WITH ETHANOL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ZAMANIAN AZODI MONA; REZAEI TAVIRANI MOSTAFA; PEYVANDI MARYAM; SAFAEI AKRAM; REZAEI TAVIRANI MAJID; MAHBOUBI MOHAMMAD; OKHOVATIAN FARSHAD; Safakhah Hossein Ali

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2016 | Volume:18 | Issue:1 (61) Page(s): 35-41

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,166

Download:

Cites:

Information Journal Paper

Title

PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF HUMAN FIBROBLAST CELLS TREATED WITH ETHANOL

Author(s)

Keywords

ETHANOLQ2

FIBROBLASTSQ1

PROTEIN INTERACTION MAPSQ1

GENE ONTOLOGYQ1

Abstract

Introduction: Studies show that ETHANOL can induce changes in proteomic profile of human fibroblast cells. Some of these proteins are important in promoting cancer. Thus, analyzing function and interaction networks of these proteins are essential for better understanding the carcinogenesis mechanism of ETHANOL.Materials and Methods: In this study the protein-protein interaction network (PPI) of six significant down-regulated proteins in human fibroblast cells (HFFF2) treated with ETHANOL were analyzed by using Cytoscape software and its algorithms.Results: PPI network analysis showed that the constructed network consisted of 756 nodes and 1166 edges. Results indicated that Heterogeneous nuclear ribonucleoprotein A1 with degree = 528 and Between ness Centrality = 0.74 is a hub protein that ETHANOL can alter its expression. In addition, module evaluation showed that the hub protein has a key role in different overlapped complexes. On the other hand, annotation studies by using DAVID program indicated that this protein is involved in different important biological processes in the cell.Conclusion: The six down-regulated proteins treated with ETHANOL may become carcinogenic and can impose vast alterations in other vital biological processes of the cell. Among them, Heterogeneous nuclear ribonucleoprotein A1 is the most important one.

Cites

No record.

References

Cite

APA: Copy

ZAMANIAN AZODI, MONA, REZAEI TAVIRANI, MOSTAFA, PEYVANDI, MARYAM, SAFAEI, AKRAM, REZAEI TAVIRANI, MAJID, MAHBOUBI, MOHAMMAD, OKHOVATIAN, FARSHAD, & Safakhah, Hossein Ali. (2016). PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF HUMAN FIBROBLAST CELLS TREATED WITH ETHANOL. KOOMESH, 18(1 (61)), 35-41. SID. https://sid.ir/paper/36991/en

Vancouver: Copy

ZAMANIAN AZODI MONA, REZAEI TAVIRANI MOSTAFA, PEYVANDI MARYAM, SAFAEI AKRAM, REZAEI TAVIRANI MAJID, MAHBOUBI MOHAMMAD, OKHOVATIAN FARSHAD, Safakhah Hossein Ali. PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF HUMAN FIBROBLAST CELLS TREATED WITH ETHANOL. KOOMESH[Internet]. 2016;18(1 (61)):35-41. Available from: https://sid.ir/paper/36991/en

IEEE: Copy

MONA ZAMANIAN AZODI, MOSTAFA REZAEI TAVIRANI, MARYAM PEYVANDI, AKRAM SAFAEI, MAJID REZAEI TAVIRANI, MOHAMMAD MAHBOUBI, FARSHAD OKHOVATIAN, and Hossein Ali Safakhah, “PROTEIN-PROTEIN INTERACTION NETWORK ANALYSIS OF HUMAN FIBROBLAST CELLS TREATED WITH ETHANOL,” KOOMESH, vol. 18, no. 1 (61), pp. 35–41, 2016, [Online]. Available: https://sid.ir/paper/36991/en

Related Journal Papers