EFFECTS OF PRAVASTATIN IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS

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MANSOURI ESRAFIL; ASSAREHZADEGAN MOHAMMAD ALI; NEJAD DEHBASHI FERESHTEH; KOOTI WESAM

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:4 Page(s): 1413-1419

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Title

EFFECTS OF PRAVASTATIN IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS

Author(s)

MANSOURI ESRAFIL | ASSAREHZADEGAN MOHAMMAD ALI | NEJAD DEHBASHI FERESHTEH | KOOTI WESAM | Issue Writer Certificate

Keywords

NEPHROPATHY

ADRIAMYCIN

PRAVASTATIN

NEPHROPROTECTIVE

RAT

Abstract

The aim of this study is to evaluate the effects of PRAVASTATIN on ADRIAMYCIN (ADR) -induced NEPHROPATHY and the mechanisms involved. Forty RATs were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus PRAVASTATIN (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus PRAVASTATIN (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 after ADR injection, the animals were sacrificed. The results showed that administration of PRAVASTATIN decreased the levels of 24-h urinary protein (24-h UP), blood urea nitrogen (BUN), and creatinine (p<0.05) which had increased after the injection of ADR; in addition, PRAVASTATIN reversed structural changes seen in ADR group. Furthermore, PRAVASTATIN elevated mRNA and protein expression of nephrin (p<0.05) which had been reduced in ADR group. We conclude that PRAVASTATIN protects and treats renal injury induced by ADR.

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APA: Copy

MANSOURI, ESRAFIL, ASSAREHZADEGAN, MOHAMMAD ALI, NEJAD DEHBASHI, FERESHTEH, & KOOTI, WESAM. (2018). EFFECTS OF PRAVASTATIN IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(4), 1413-1419. SID. https://sid.ir/paper/288911/en

Vancouver: Copy

MANSOURI ESRAFIL, ASSAREHZADEGAN MOHAMMAD ALI, NEJAD DEHBASHI FERESHTEH, KOOTI WESAM. EFFECTS OF PRAVASTATIN IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(4):1413-1419. Available from: https://sid.ir/paper/288911/en

IEEE: Copy

ESRAFIL MANSOURI, MOHAMMAD ALI ASSAREHZADEGAN, FERESHTEH NEJAD DEHBASHI, and WESAM KOOTI, “EFFECTS OF PRAVASTATIN IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 4, pp. 1413–1419, 2018, [Online]. Available: https://sid.ir/paper/288911/en

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