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Title

A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for Cervical Ripening Prior to Labor Induction in Iranian Pregnant Women

Pages

  988-994

Abstract

 Our aim was to examine the effect and cost-effectiveness of Isosorbide mononitrate (IMN) for outpatient (at home) Cervical ripening in Iranian women with term pregnancy. Term pregnant women were randomly selected to receive either 15 mg vaginally administered IMN or placebo. Patients were advised to take the second dose at home 24 h later and return to the hospital for admission after the next 24 h if the onset of spontaneous contraction does not occur. Cervical status, maternal blood pressure, maternal pulse rate, fetal heart rate and various side effects were examined. IMN induced a significant increase in cervical Bishop score; headache, nausea, and dizziness were seen in 8 of 28 participants of IMN group; although, all had normal vital signs and normal FHR, they had to be hospitalized and receive medication to relieve the unpleasant symptoms. Vaginal administration of 15 mg of IMN induced Cervical ripening in Term pregnant women. However, the administration of IMN for Cervical ripening is not recommended as it produced headache in significant number of Iranian pregnant women.

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    APA: Copy

    Abotorabi, Shokohosadat, MOHAMMADI, MASOOMEH, BAGHERIVAND, SAMIRA, & OVEISI, SONIA. (2019). A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for Cervical Ripening Prior to Labor Induction in Iranian Pregnant Women. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 18(2), 988-994. SID. https://sid.ir/paper/289111/en

    Vancouver: Copy

    Abotorabi Shokohosadat, MOHAMMADI MASOOMEH, BAGHERIVAND SAMIRA, OVEISI SONIA. A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for Cervical Ripening Prior to Labor Induction in Iranian Pregnant Women. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2019;18(2):988-994. Available from: https://sid.ir/paper/289111/en

    IEEE: Copy

    Shokohosadat Abotorabi, MASOOMEH MOHAMMADI, SAMIRA BAGHERIVAND, and SONIA OVEISI, “A Pilot Randomized Controlled Trial to Evaluate Isosorbide Mononitrate (IMN) Efficiency for Cervical Ripening Prior to Labor Induction in Iranian Pregnant Women,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 18, no. 2, pp. 988–994, 2019, [Online]. Available: https://sid.ir/paper/289111/en

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