THE IMPACT OF HLA-E POLYMORPHISMS IN GRAFT-VERSUS-HOST DISEASE FOLLOWING HLA-E MATCHED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

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HOSSEINI EHTERAMOLSADAT; SCHWARER ANTHONY P.; GHASEMZADEH MEHRAN

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2012 | Volume:11 | Issue:1 Page(s): 15-21

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Title

THE IMPACT OF HLA-E POLYMORPHISMS IN GRAFT-VERSUS-HOST DISEASE FOLLOWING HLA-E MATCHED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Author(s)

HOSSEINI EHTERAMOLSADAT | SCHWARER ANTHONY P. | GHASEMZADEH MEHRAN | Issue Writer Certificate

Keywords

GRAFT-VERSUS-HOST DISEASE

HEMATOPOIETIC STEM CELL TRANSPLANTATION

HLA-E POLYMORPHISMS

OVERALL SURVIVAL

Abstract

The non-classical MHC class-I mainly involves in the regulation of innate immune responses where HLA-E plays a significant role in the cell identification by natural killer cells. HLA-E is a main regulatory ligand for natural killer cells and given the importance of these effector cells in HEMATOPOIETIC STEM CELL TRANSPLANTATION, we investigated the effect of HLA-E POLYMORPHISMS on post-hematopoietic stem cell transplantation outcomes.The study group included 56 donor-patient pairs with underlying malignant hematological disorders undergoing HLA-E matched allogeneic HEMATOPOIETIC STEM CELL TRANSPLANTATION.They were genotyped for HLA-E locus using a sequence specific primer-polymerase chain reaction. The median follow-up was 20.6 months (range 0.2-114.8) and the parameters assessed were acute and chronic GRAFT-VERSUS-HOST DISEASE and OVERALL SURVIVAL.We showed a lower frequency of acute GRAFT-VERSUS-HOST DISEASE (grade II or more; p=0.02) and chronic GRAFT-VERSUS-HOST DISEASE (extensive; p=0.04) in the patients with HLAE*0103/0103 genotype compared to other genotypes of HLA-E. There was also an association between HLA-E*0103/0103 and improved OVERALL SURVIVAL (p=0.001).Conclusively, our results suggest a protective role for HLA-E*0103/0103 genotype against acute GRAFT-VERSUS-HOST DISEASE (grade II or more) and chronic GRAFT-VERSUS-HOST DISEASE (extensive) as well as an association between this genotype and a better OVERALL SURVIVAL after HLA-E matched allogeneic HEMATOPOIETIC STEM CELL TRANSPLANTATION.

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APA: Copy

HOSSEINI, EHTERAMOLSADAT, SCHWARER, ANTHONY P., & GHASEMZADEH, MEHRAN. (2012). THE IMPACT OF HLA-E POLYMORPHISMS IN GRAFT-VERSUS-HOST DISEASE FOLLOWING HLA-E MATCHED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 11(1), 15-21. SID. https://sid.ir/paper/291323/en

Vancouver: Copy

HOSSEINI EHTERAMOLSADAT, SCHWARER ANTHONY P., GHASEMZADEH MEHRAN. THE IMPACT OF HLA-E POLYMORPHISMS IN GRAFT-VERSUS-HOST DISEASE FOLLOWING HLA-E MATCHED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2012;11(1):15-21. Available from: https://sid.ir/paper/291323/en

IEEE: Copy

EHTERAMOLSADAT HOSSEINI, ANTHONY P. SCHWARER, and MEHRAN GHASEMZADEH, “THE IMPACT OF HLA-E POLYMORPHISMS IN GRAFT-VERSUS-HOST DISEASE FOLLOWING HLA-E MATCHED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 11, no. 1, pp. 15–21, 2012, [Online]. Available: https://sid.ir/paper/291323/en

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