مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

ASSOCIATION OF HLA-DRB1 ALLELES WITH ULCERATIVE COLITIS IN THE CITY OF KERMAN, SOUTH EASTERN IRAN

Pages

  306-312

Abstract

 The association of HLA class II genes with ULCERATIVE COLITIS (UC) as an autoimmune disease has been investigated for several years. However, factors responsible for genetic predisposition of this disease have so far not been clearly understood. In this study, for the first time, we aimed to investigate the association between HLA-DRB1 types and UC in the population of Kerman, a city southeast IRAN.HLA typing was performed among 85 UC patients and 95 healthy controls using PCR amplification, employing sequence specific primers (PCR-SSP). The DRB1 frequencies were determined in the patients and controls.HLA-DRB1*04 was negatively associated with UC. Furthermore, HLA-DRB1*13 was significantly associated with severity of the disease (p=0.01) among UC patients.This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.

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    APA: Copy

    MOHAMMADI, MOJGAN, RASTIN, MARYAM, RAFATPANAH, HOUSHANG, ABDOLI SERESHKI, HALEH, ZAHEDI, MOHAMMAD JAVAD, NIKPOOR, AMIN REZA, BANESHI, MOHAMMAD REZA, & HAYATBAKHSH, MOHAMMAD MEHDI. (2015). ASSOCIATION OF HLA-DRB1 ALLELES WITH ULCERATIVE COLITIS IN THE CITY OF KERMAN, SOUTH EASTERN IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 306-312. SID. https://sid.ir/paper/291448/en

    Vancouver: Copy

    MOHAMMADI MOJGAN, RASTIN MARYAM, RAFATPANAH HOUSHANG, ABDOLI SERESHKI HALEH, ZAHEDI MOHAMMAD JAVAD, NIKPOOR AMIN REZA, BANESHI MOHAMMAD REZA, HAYATBAKHSH MOHAMMAD MEHDI. ASSOCIATION OF HLA-DRB1 ALLELES WITH ULCERATIVE COLITIS IN THE CITY OF KERMAN, SOUTH EASTERN IRAN. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):306-312. Available from: https://sid.ir/paper/291448/en

    IEEE: Copy

    MOJGAN MOHAMMADI, MARYAM RASTIN, HOUSHANG RAFATPANAH, HALEH ABDOLI SERESHKI, MOHAMMAD JAVAD ZAHEDI, AMIN REZA NIKPOOR, MOHAMMAD REZA BANESHI, and MOHAMMAD MEHDI HAYATBAKHSH, “ASSOCIATION OF HLA-DRB1 ALLELES WITH ULCERATIVE COLITIS IN THE CITY OF KERMAN, SOUTH EASTERN IRAN,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 306–312, 2015, [Online]. Available: https://sid.ir/paper/291448/en

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