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Information Journal Paper

Title

HUMAN LEUKOCYTE ANTIGENS INFLUENCE THE ANTIBODY RESPONSE TO HEPATITIS B VACCINE (REVIEW ARTICLE)

Pages

  233-245

Abstract

 Hepatitis B virus (HBV) infection and its sequelae such as cirrhosis and hepatocellular carcinoma has remained a serious public health problem throughout the world. The WHO strategy for effective control of HBV infection and its complications is mass vaccination of neonates and children within the framework of Expanded Programme on Immunization (EPI). Vaccination with hepatitis B surface antigen (HBsAg) induces protective antibody response (anti-HBs³10 IU/L) in 90-99% of vaccinees.The lack of response to HBsAg has been attributed to a variety of immunological mechanisms, including defect in antigen presentation, defect in HBsAg-specific T and/or B cell repertoires, T-cell suppression, increase in the regulatory T cell count, lack of necessary help of T-cells for production of anti-HBs by B cells, defect in Th1 and/or Th2 cytokine production and selective killing of HBsAg-specific B-cells by HUMAN LEUKOCYTE ANTIGEN (HLA)-restricted cytotoxic T lymphocytes. The HLA complex plays an important role in many of these immunological processes.A variety of HLA class I, II, and III alleles and antigens have been reported to be associated with antibody response to HBsAg vaccination in different ethnic populations. Moreover, some HLA haplotypes were also associated with responsiveness to HBsAg.In this review the association of the HLA specificities with antibody response to hepatitis B (HB) vaccine is discussed.

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    Cite

    APA: Copy

    JAFARZADEH, ABDOLLAH, BAGHERI JAMEBOZORGI, MASOOME, NEMATI, MARYAM, GOLSAZ SHIRAZI, FOROUGH, & SHOKRI, FAZEL. (2015). HUMAN LEUKOCYTE ANTIGENS INFLUENCE THE ANTIBODY RESPONSE TO HEPATITIS B VACCINE (REVIEW ARTICLE). IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(3), 233-245. SID. https://sid.ir/paper/291449/en

    Vancouver: Copy

    JAFARZADEH ABDOLLAH, BAGHERI JAMEBOZORGI MASOOME, NEMATI MARYAM, GOLSAZ SHIRAZI FOROUGH, SHOKRI FAZEL. HUMAN LEUKOCYTE ANTIGENS INFLUENCE THE ANTIBODY RESPONSE TO HEPATITIS B VACCINE (REVIEW ARTICLE). IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(3):233-245. Available from: https://sid.ir/paper/291449/en

    IEEE: Copy

    ABDOLLAH JAFARZADEH, MASOOME BAGHERI JAMEBOZORGI, MARYAM NEMATI, FOROUGH GOLSAZ SHIRAZI, and FAZEL SHOKRI, “HUMAN LEUKOCYTE ANTIGENS INFLUENCE THE ANTIBODY RESPONSE TO HEPATITIS B VACCINE (REVIEW ARTICLE),” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 3, pp. 233–245, 2015, [Online]. Available: https://sid.ir/paper/291449/en

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