IDENTIFICATION OF ASPERGILLUS (A FLAVUS AND A NIGER) ALLERGENS AND HETEROGENEITY OF ALLERGIC PATIENTS’ IGE RESPONSE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VERMANI MAANSI; KANDI VIJAYAN VANNAN; AGARWAL MAHENDRA KUMAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2015 | Volume:14 | Issue:4 Page(s): 361-369

Download Full-Text

View:

438

Download:

192

Cites:

Information Journal Paper

Title

IDENTIFICATION OF ASPERGILLUS (A FLAVUS AND A NIGER) ALLERGENS AND HETEROGENEITY OF ALLERGIC PATIENTS’ IGE RESPONSE

Author(s)

VERMANI MAANSI | KANDI VIJAYAN VANNAN | AGARWAL MAHENDRA KUMAR | Issue Writer Certificate

Keywords

ALLERGENS

ASPERGILLUS FLAVUS

ASPERGILLUS NIGER

HETEROGENEITY

IGE RESPONSE

IMMUNOBLOTTING

Abstract

Aspergillus species (A flavus and A niger) are important sources of inhalant ALLERGENS. Current diagnostic modalities employ crude Aspergillus extracts which only indicate the source to which the patient has been sensitized, without identifying the number and type of ALLERGENS in crude extracts. We report a study on the identification of major and minor ALLERGENS of the two common airborne Aspergillus species and HETEROGENEITY of patients’ IGE RESPONSE to them.Skin prick tests were performed on 300 patients of bronchial asthma and/or allergic rhinitis and 20 healthy volunteers. Allergen specific IgE in patients’ sera was estimated by enzyme allergosorbent test (EAST). Immunoblots were performed to identify major/minor ALLERGENS of Aspergillus extracts and to study HETEROGENEITY of patients’ IGE RESPONSE to them.Positive cutaneous responses were observed in 17% and 14.7% of patients with A flavus and A niger extracts, respectively. Corresponding EAST positivity was 69.2% and 68.7%. In immunoblots, 5 allergenic proteins were identified in A niger extract, major ALLERGENS being 49, 55.4 and 81.5 kDa. Twelve proteins bound patients’ IgE in A flavus extract, three being major ALLERGENS (13.3, 34 and 37 kDa). The position and slopes of EAST binding and inhibition curves obtained with individual sera varied from patient to patient. The number and molecular weight of IgE-binding proteins in both the Aspergillus extracts varied among patients.These results gave evidence of HETEROGENEITY of patients’ IGE RESPONSE to major/minor Aspergillus ALLERGENS. This approach will be helpful to identify disease eliciting molecules in the individual patients (component resolved diagnosis) and may improve allergen-specific immunotherapy.

Cites

COMPARISON OF IGE-REACTIVITY OF ASPERGILLUS FUMIGATUS, ASPERGILLUS FLAVOUS AND ASPERGILLUS NIGER WITH TYPE 1 HYPERSENSITIVE PATIENTS’ SERA

References

No record.

Cite

APA: Copy

VERMANI, MAANSI, KANDI VIJAYAN, VANNAN, & AGARWAL, MAHENDRA KUMAR. (2015). IDENTIFICATION OF ASPERGILLUS (A FLAVUS AND A NIGER) ALLERGENS AND HETEROGENEITY OF ALLERGIC PATIENTS’ IGE RESPONSE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 14(4), 361-369. SID. https://sid.ir/paper/291472/en

Vancouver: Copy

VERMANI MAANSI, KANDI VIJAYAN VANNAN, AGARWAL MAHENDRA KUMAR. IDENTIFICATION OF ASPERGILLUS (A FLAVUS AND A NIGER) ALLERGENS AND HETEROGENEITY OF ALLERGIC PATIENTS’ IGE RESPONSE. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2015;14(4):361-369. Available from: https://sid.ir/paper/291472/en

IEEE: Copy

MAANSI VERMANI, VANNAN KANDI VIJAYAN, and MAHENDRA KUMAR AGARWAL, “IDENTIFICATION OF ASPERGILLUS (A FLAVUS AND A NIGER) ALLERGENS AND HETEROGENEITY OF ALLERGIC PATIENTS’ IGE RESPONSE,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 14, no. 4, pp. 361–369, 2015, [Online]. Available: https://sid.ir/paper/291472/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops