TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISM AT POSITION-238 IN PREECLAMPSIA

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NADERI MOHAMMAD; YAGHOOTKAR HANIEH; TARA FATEMEH; TAVAKKOL AFSHARI JALIL; FARID HOSSEINI REZA; GHAYOUR MOBARHAN MAJID; SHAPOURI MOGHADAM ABBAS; MIRTEIMOURI MASOUMEH; TARA SEYEDEH MARYAM

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Journal: Iranian Red Crescent Medical Journal Year:2014 | Volume:16 | Issue:1 Page(s): 1-5

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Title

TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISM AT POSITION-238 IN PREECLAMPSIA

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Keywords

TUMOR NECROSIS FACTOR-ALPHA

PRE-ECLAMPSIA

POLYMORPHISM

GENETIC

Abstract

Background: Preeclampsia is the most common serious disorder during pregnancy and studies show several immune-related processes in its pathophysiology. The role of cytokines and their expression remains controversial in this field. One of the cytokines of interest in recent studies has been TNF-a, which has been shown to have a higher level in maternal plasma of preeclamptic women.Objectives: This study was designed to evaluate the role of TNF-a POLYMORPHISM at position -238 in the risk of developing preeclampsia during pregnancy.Patients and Methods: One hundred fifty three preeclamptic cases and 140 healthy pregnant women were retrieved from two major hospitals of Mashhad, Iran. Methods a case-control study were designed. Anyone with a history of inflammatory disease, hypertension, or chronic kidney disease was excluded. DNA was extracted from peripheral blood leukocytes. Both groups were genotyped for the POLYMORPHISM of the TNF-a gene at position -238 by the RFLP method with Ava II enzyme. Allele and genotype frequencies were compared using one-way ANOVA and the Fisher's exact test.Results: There were significant differences between the two groups in TNF-a genotype at position -238 (P<0.001). In the preeclamptic group, the frequency of the AA genotype was higher (P<0.001) and the frequency of the GG genotype was lower (P<0.001). The overall prevalence of the A allele at position -238 was higher in preeclamptic cases (P<0.001).Conclusion: In this study group, TNF-a -238 POLYMORPHISM was shown to be different in preeclamptic and non-preeclamptic pregnant women. The AA genotype and the A allele may carry an increased risk for developing of preeclampsia.

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APA: Copy

NADERI, MOHAMMAD, YAGHOOTKAR, HANIEH, TARA, FATEMEH, TAVAKKOL AFSHARI, JALIL, FARID HOSSEINI, REZA, GHAYOUR MOBARHAN, MAJID, SHAPOURI MOGHADAM, ABBAS, MIRTEIMOURI, MASOUMEH, & TARA, SEYEDEH MARYAM. (2014). TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISM AT POSITION-238 IN PREECLAMPSIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 16(1), 1-5. SID. https://sid.ir/paper/292565/en

Vancouver: Copy

NADERI MOHAMMAD, YAGHOOTKAR HANIEH, TARA FATEMEH, TAVAKKOL AFSHARI JALIL, FARID HOSSEINI REZA, GHAYOUR MOBARHAN MAJID, SHAPOURI MOGHADAM ABBAS, MIRTEIMOURI MASOUMEH, TARA SEYEDEH MARYAM. TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISM AT POSITION-238 IN PREECLAMPSIA. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2014;16(1):1-5. Available from: https://sid.ir/paper/292565/en

IEEE: Copy

MOHAMMAD NADERI, HANIEH YAGHOOTKAR, FATEMEH TARA, JALIL TAVAKKOL AFSHARI, REZA FARID HOSSEINI, MAJID GHAYOUR MOBARHAN, ABBAS SHAPOURI MOGHADAM, MASOUMEH MIRTEIMOURI, and SEYEDEH MARYAM TARA, “TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISM AT POSITION-238 IN PREECLAMPSIA,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 16, no. 1, pp. 1–5, 2014, [Online]. Available: https://sid.ir/paper/292565/en

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