APPLICATION OF SMOOTHING METHODS FOR DETERMINING OF THE EFFECTING FACTORS ON THE SURVIVAL RATE OF GASTRIC CANCER PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOORKOJURI HODA; HAJIZADEH EBRAHIM; BAGHESTANI AHMADREZA; POURHOSEINGHOLI MOHAMADAMIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:2 Page(s): 166-172

Download Full-Text

View:

300

Download:

147

Cites:

Information Journal Paper

Title

APPLICATION OF SMOOTHING METHODS FOR DETERMINING OF THE EFFECTING FACTORS ON THE SURVIVAL RATE OF GASTRIC CANCER PATIENTS

Author(s)

NOORKOJURI HODA | HAJIZADEH EBRAHIM | BAGHESTANI AHMADREZA | POURHOSEINGHOLI MOHAMADAMIN | Issue Writer Certificate

Keywords

PROPORTIONAL HAZARDS MODELS; SURVIVAL; STOMACH NEOPLASMS

Abstract

Background: Smoothing methods are widely used to analyze epidemiologic data, particularly in the area of environmental health where non-linear relationships are not uncommon. This study focused on three different smoothing methods in Cox models: penalized splines, restricted cubic splines and fractional polynomials.Objectives: The aim of this study was to assess the effects of prognostic factors on survival of patients with gastric cancer using the smoothing methods in Cox model and Cox proportional hazards. Also, all models were compared to each other in order to find the best one.Materials and Methods: We retrospectively studied 216 patients with gastric cancer who were registered in one referral cancer registry center in Tehran, Iran. Age at diagnosis, sex, presence of metastasis, tumor size, histology type, lymph node metastasis, and pathologic stages were entered in to analysis using the Cox proportional hazards model and smoothing methods in Cox model. The SPSS version 18.0 and R version 2.14.1 were used for data analysis. These models compared with Akaike information criterion.Results: In this study, The 5 year survival rate was 30%. The Cox proportional hazards, penalized spline and fractional polynomial models let to similar results and Akaike information criterion showed a better performance for these three models comparing to the restricted cubic spline. Also, P-value and likelihood ratio test in restricted cubic spline was greater than other models. Note that the best model is indicated by the lowest Akaike information criterion.Conclusions: The use of smoothing methods helps us to eliminate non-linear effects but it is more appropriate to use Cox proportional hazards model in medical data because of its’ ease of interpretation and capability of modeling both continuous and discrete covariates. Also, Cox proportional hazards model and smoothing methods analysis identified that age at diagnosis and tumor size were independent prognostic factors for the survival of patients with gastric cancer (P dlt; 0.05). According to these results the early detection of patients at younger age and in primary stages may be important to increase survival.

Cites

No record.

References

No record.

Cite

APA: Copy

NOORKOJURI, HODA, HAJIZADEH, EBRAHIM, BAGHESTANI, AHMADREZA, & POURHOSEINGHOLI, MOHAMADAMIN. (2013). APPLICATION OF SMOOTHING METHODS FOR DETERMINING OF THE EFFECTING FACTORS ON THE SURVIVAL RATE OF GASTRIC CANCER PATIENTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 166-172. SID. https://sid.ir/paper/292812/en

Vancouver: Copy

NOORKOJURI HODA, HAJIZADEH EBRAHIM, BAGHESTANI AHMADREZA, POURHOSEINGHOLI MOHAMADAMIN. APPLICATION OF SMOOTHING METHODS FOR DETERMINING OF THE EFFECTING FACTORS ON THE SURVIVAL RATE OF GASTRIC CANCER PATIENTS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):166-172. Available from: https://sid.ir/paper/292812/en

IEEE: Copy

HODA NOORKOJURI, EBRAHIM HAJIZADEH, AHMADREZA BAGHESTANI, and MOHAMADAMIN POURHOSEINGHOLI, “APPLICATION OF SMOOTHING METHODS FOR DETERMINING OF THE EFFECTING FACTORS ON THE SURVIVAL RATE OF GASTRIC CANCER PATIENTS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 166–172, 2013, [Online]. Available: https://sid.ir/paper/292812/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops