THE ANTIMICROBIAL EFFECT OF LACTOBACILLUS CASEI CULTURE SUPERNATANT AGAINST MULTIPLE DRUG RESISTANT CLINICAL ISOLATES OF SHIGELLA SONNEI AND SHIGELLA FLEXNERI IN VITRO

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MIRNEJAD REZA; VAHDATI ALI REZA; RASHIDIANI JAMAL; ERFANI MOHAMMAD; PIRANFAR VAHHAB

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2013 | Volume:15 | Issue:2 Page(s): 122-126

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Title

THE ANTIMICROBIAL EFFECT OF LACTOBACILLUS CASEI CULTURE SUPERNATANT AGAINST MULTIPLE DRUG RESISTANT CLINICAL ISOLATES OF SHIGELLA SONNEI AND SHIGELLA FLEXNERI IN VITRO

Author(s)

Keywords

LACTOBACILLUS CASEI

SHIGELLA FLEXNERI

SHIGELLA SONNEI

Abstract

Backgrounds: Shigellosis remains an important public health problem in developing countries with S. sonnei and S. flexneri in US, Europe and in Asian countries being of importance.Objectives: This study evaluates the protective effect of LACTOBACILLUS CASEI cell-free culture supernatants (CFCS) against multiple drug resistance (MDR) clinical samples of SHIGELLA SONNEI and SHIGELLA FLEXNERI in vitro.Materials and Methods: S. sonnei and S .flexneri was identified by common microbiological and serological methods. Antibiogram with 18 antibiotics were tested for 34 positive cultures by disc diffusion method. The Samples showed considerable resistance to antibiotics. Antimicrobial effects of CFCS were tested against S. sonnei and S. flexneri by agar-well assay and broth micro dilution methods. In addition, the antimicrobial activity remained active treatment after adjust pH 7, adding Proteinase K and heating for L. casei.Results: The results implicate that L. casei strongly inhibits the development of pathogen samples. In contrast, via the disc diffusion method 4 out of 18 antibiogram have shown complete resistance against the pathogen samples. In addition, the natures of antimicrobial properties have been tested in different conditions such as various pH, temperature and presence of proteinase K. The MIC50 (minimum inhibitory concentration) and MIC90 of CFCS of L. casei were determined, for S. sonnei were 2.25 and 10.5, for S .flexneri were 5.25 and 5.25 respectively. The results have shown a significant resistance pattern by these four antibiotics in this case.Conclusions: The data indicates that. L. casei highly resistant against to antibiotics, heat, Proteinase K and so many activities against MDR Shigella pathogenic strains . L. casei is the best probiotics candidate.

Cites

ANTIBACTERIAL ACTIVITY AND EFFICIENT SYNTHESIS OF 3,4 DIHYDROPYRANO [C] CHROMENE DERIVATIVES BY USING AMMONIUM TRIFLUOROACETATE (CF3COONH4) CATALYST

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APA: Copy

MIRNEJAD, REZA, VAHDATI, ALI REZA, RASHIDIANI, JAMAL, ERFANI, MOHAMMAD, & PIRANFAR, VAHHAB. (2013). THE ANTIMICROBIAL EFFECT OF LACTOBACILLUS CASEI CULTURE SUPERNATANT AGAINST MULTIPLE DRUG RESISTANT CLINICAL ISOLATES OF SHIGELLA SONNEI AND SHIGELLA FLEXNERI IN VITRO. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 15(2), 122-126. SID. https://sid.ir/paper/292813/en

Vancouver: Copy

MIRNEJAD REZA, VAHDATI ALI REZA, RASHIDIANI JAMAL, ERFANI MOHAMMAD, PIRANFAR VAHHAB. THE ANTIMICROBIAL EFFECT OF LACTOBACILLUS CASEI CULTURE SUPERNATANT AGAINST MULTIPLE DRUG RESISTANT CLINICAL ISOLATES OF SHIGELLA SONNEI AND SHIGELLA FLEXNERI IN VITRO. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2013;15(2):122-126. Available from: https://sid.ir/paper/292813/en

IEEE: Copy

REZA MIRNEJAD, ALI REZA VAHDATI, JAMAL RASHIDIANI, MOHAMMAD ERFANI, and VAHHAB PIRANFAR, “THE ANTIMICROBIAL EFFECT OF LACTOBACILLUS CASEI CULTURE SUPERNATANT AGAINST MULTIPLE DRUG RESISTANT CLINICAL ISOLATES OF SHIGELLA SONNEI AND SHIGELLA FLEXNERI IN VITRO,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 15, no. 2, pp. 122–126, 2013, [Online]. Available: https://sid.ir/paper/292813/en

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