INCREASED INTERLEUKIN-17 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS, A LINK BETWEEN T-HELPER 17 AND PROINFLAMMATORY RESPONSES IN BLADDER CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAHARLOU RASOUL; KHEZRI ABDOLAZIZ; RAZMKHAH MAHBOOBEH; HABIBAGAHI MOJTABA; HOSSEINI AHMAD; GHADERI ABBAS; JABERIPOUR MANSOOREH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Red Crescent Medical Journal Year:2015 | Volume:17 | Issue:2 Page(s): 0-0

Download Full-Text

View:

419

Download:

146

Cites:

Information Journal Paper

Title

INCREASED INTERLEUKIN-17 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS, A LINK BETWEEN T-HELPER 17 AND PROINFLAMMATORY RESPONSES IN BLADDER CANCER

Author(s)

Keywords

INTERLEUKIN 6

INTERLEUKIN 17

TRANSFORMING GROWTH FACTOR BETA

Abstract

Background: Interleukin (IL) -17-producing CD4+T helper (Th17) cells thatare known by producing IL-17 have recently been defined as a unique subset of proinflammatory helper cells. IL-17 is an inflammatory cytokine with robust effect on many cells and it can play important roles in pathogenesis of diverse groups of immune-mediated diseases.Objectives: The aim of this case-control study was to determine the gene expression of IL-6, IL-17, and TRANSFORMING GROWTH FACTOR BETA (TGF-b) in Iranian patients with bladder cancer.Patients and Methods: Blood samples were collected from 37 patients with bladder cancer and 37 healthy individuals with no history of malignancies or autoimmune disorders, based of simple sampling. The expression of IL-6, IL-17, and TGF-b were measured by quantitative real-time polymerase chain reaction (qRT-PCR).Results: The mean of IL-17 transcripts was significantly higher in patients with bladder cancer compared with healthy individuals (0.33±0.06 vs.0.42±0.14,) (P=0.04), but their TGF-b was lower (12.53±8.41 vs.54.94±17.95,) (P=0.04). However, the IL-6 transcripts level was similar in both groups (5.34±2.40 vs.8.07±3.28,) (P>0.05) and there was not any significant difference between the noted cytokines expressions among patients with different stages and grades.Conclusions: As most of the cases studied in this investigation were in stages I and II, IL-17 as a prominent proinflammatory cytokine may play an important role in recruiting and infiltrating of antitumor immune responses in early stages of bladder cancer. Furthermore, it can be used as predictor for the clinical stage and prognosis of cancers such as bladder carcinoma.

Cites

No record.

References

Cite

APA: Copy

BAHARLOU, RASOUL, KHEZRI, ABDOLAZIZ, RAZMKHAH, MAHBOOBEH, HABIBAGAHI, MOJTABA, HOSSEINI, AHMAD, GHADERI, ABBAS, & JABERIPOUR, MANSOOREH. (2015). INCREASED INTERLEUKIN-17 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS, A LINK BETWEEN T-HELPER 17 AND PROINFLAMMATORY RESPONSES IN BLADDER CANCER. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 17(2), 0-0. SID. https://sid.ir/paper/293065/en

Vancouver: Copy

BAHARLOU RASOUL, KHEZRI ABDOLAZIZ, RAZMKHAH MAHBOOBEH, HABIBAGAHI MOJTABA, HOSSEINI AHMAD, GHADERI ABBAS, JABERIPOUR MANSOOREH. INCREASED INTERLEUKIN-17 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS, A LINK BETWEEN T-HELPER 17 AND PROINFLAMMATORY RESPONSES IN BLADDER CANCER. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2015;17(2):0-0. Available from: https://sid.ir/paper/293065/en

IEEE: Copy

RASOUL BAHARLOU, ABDOLAZIZ KHEZRI, MAHBOOBEH RAZMKHAH, MOJTABA HABIBAGAHI, AHMAD HOSSEINI, ABBAS GHADERI, and MANSOOREH JABERIPOUR, “INCREASED INTERLEUKIN-17 TRANSCRIPTS IN PERIPHERAL BLOOD MONONUCLEAR CELLS, A LINK BETWEEN T-HELPER 17 AND PROINFLAMMATORY RESPONSES IN BLADDER CANCER,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 17, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/293065/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops