MODIFIED ULTRAFILTRATION IN CORONARY ARTERY BYPASS GRAFTING: ARANDOMIZED, DOUBLE-BLINDED, CONTROLLED CLINICAL TRIAL

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SADEGHPOUR TABAEI ALI; MORTAZIAN MEYSAM; YAGHOUBI ALIREZA; GORJIPOUR FARHAD; ARASTEH MANESH SHAGHAYEGH; TOTONCHI ZIAE; BAHARESTANI BAHADOR; MEHRABANIAN MOHAMMAD JAVAD; PAZOKI TOROUDI HAMIDREZA; KAVEH HOSSEIN; TOLOUEITABAR YASER; GHANBARI AMENEH; GORJIPOUR FAZEL

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Journal: Iranian Red Crescent Medical Journal Year:2018 | Volume:20 | Issue:5 Page(s): 0-0

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Title

MODIFIED ULTRAFILTRATION IN CORONARY ARTERY BYPASS GRAFTING: ARANDOMIZED, DOUBLE-BLINDED, CONTROLLED CLINICAL TRIAL

Author(s)

Keywords

CYTOKINE

HEMATOCRIT

HEMOGLOBIN

INFLAMMATORY RESPONSE

MODIFIED ULTRAFILTRATION

THROMBOELASTOGRAPHY

Abstract

Background: MODIFIED ULTRAFILTRATION (MUF) has been used in Cardiopulmonary Bypass (CPB) operations to prevent hemodilutionand remove pro-inflammatory CYTOKINEs. It has been studied in pediatric operation settings. However, evidence exists regarding itsapplication in adults’ Coronary Artery Bypass Grafting (CABG) operation. Objectives: The present study investigated MUF and its effects on inflammatory CYTOKINE response, hemodilution and rotationalthromboelastometry outcomes in adults’ CABG operation. Methods: In a randomized controlled trial, 56 elective CABG patients that had referred to the Rajaie Cardiovascular Medical andResearch Center (Tehran, Iran) during year 2017 were randomly assigned to two groups, including control and MUF groups. Preoperativeand postoperative clinical parameters were recorded. Serum level of inflammatory CYTOKINEs after clamp removal, afterCardiopulmonary Bypass (CPB) (MUF in the MUF group) and 24 hours after Intensive Care Unit (ICU) entrance, and RotationalThrombo-elastometry (ROTEM) indices, pre-operation, and post-operation, were measured. Results: The two groups were similar in clinical perioperative parameters, including hemodynamics, transfusions, ROTEM indices, mechanical ventilation and CPB time, and ICU stay. The levels of inflammatory mediators were significantly increased after CPB inboth groups. Interleukin (IL)-6,-8 and-10 measures were equal between the two groups in all trial measurement points. The MUFgroup demonstrated a significantly lower level of Tumor Necrosis Factor (TNF)- compared with the control group after CPB (1. 55 0. 29 versus 1. 77 0. 35 log10 pg/mL, respectively; P = 0. 031). HEMOGLOBIN (9. 55 0. 96 versus 8. 29 0. 57 g/dl, P < 0. 001) andhematocrit % (29. 96 3. 23 and 24. 72 1. 62, P < 0. 001) levels were significantly higher in the MUF group compared with the control, after CPB. Conclusions: MODIFIED ULTRAFILTRATION eliminates extra liquids and TNF- from circulation in adults CABG operation, without affectingthe hemostatic indices and improves HEMOGLOBIN level. It does not remove anti-inflammatory CYTOKINE IL-10 from circulation.

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APA: Copy

SADEGHPOUR TABAEI, ALI, MORTAZIAN, MEYSAM, YAGHOUBI, ALIREZA, GORJIPOUR, FARHAD, ARASTEH MANESH, SHAGHAYEGH, TOTONCHI, ZIAE, BAHARESTANI, BAHADOR, MEHRABANIAN, MOHAMMAD JAVAD, PAZOKI TOROUDI, HAMIDREZA, KAVEH, HOSSEIN, TOLOUEITABAR, YASER, GHANBARI, AMENEH, & GORJIPOUR, FAZEL. (2018). MODIFIED ULTRAFILTRATION IN CORONARY ARTERY BYPASS GRAFTING: ARANDOMIZED, DOUBLE-BLINDED, CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(5), 0-0. SID. https://sid.ir/paper/293747/en

Vancouver: Copy

SADEGHPOUR TABAEI ALI, MORTAZIAN MEYSAM, YAGHOUBI ALIREZA, GORJIPOUR FARHAD, ARASTEH MANESH SHAGHAYEGH, TOTONCHI ZIAE, BAHARESTANI BAHADOR, MEHRABANIAN MOHAMMAD JAVAD, PAZOKI TOROUDI HAMIDREZA, KAVEH HOSSEIN, TOLOUEITABAR YASER, GHANBARI AMENEH, GORJIPOUR FAZEL. MODIFIED ULTRAFILTRATION IN CORONARY ARTERY BYPASS GRAFTING: ARANDOMIZED, DOUBLE-BLINDED, CONTROLLED CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(5):0-0. Available from: https://sid.ir/paper/293747/en

IEEE: Copy

ALI SADEGHPOUR TABAEI, MEYSAM MORTAZIAN, ALIREZA YAGHOUBI, FARHAD GORJIPOUR, SHAGHAYEGH ARASTEH MANESH, ZIAE TOTONCHI, BAHADOR BAHARESTANI, MOHAMMAD JAVAD MEHRABANIAN, HAMIDREZA PAZOKI TOROUDI, HOSSEIN KAVEH, YASER TOLOUEITABAR, AMENEH GHANBARI, and FAZEL GORJIPOUR, “MODIFIED ULTRAFILTRATION IN CORONARY ARTERY BYPASS GRAFTING: ARANDOMIZED, DOUBLE-BLINDED, CONTROLLED CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 5, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293747/en

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