The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits

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Saghahazrati Saeid; Ayatollahi Seyed Abdulmajid; KOBARFARD FARZAD; MINAEI BAGHER

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2019 | Volume:21 | Issue:2 Page(s): 0-0

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Title

The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits

Author(s)

Saghahazrati Saeid | Ayatollahi Seyed Abdulmajid | KOBARFARD FARZAD | MINAEI BAGHER | Issue Writer Certificate

Keywords

Diabetes Mellitus

Glucagon-Like Peptide 1

Insulin Producing Cells

Matricaria

Mesenchymal Stem Cells

Oil

Type 1

Abstract

Background: Although Matricaria chamomilla L. Oil has been shown to contribute to the differentiation of Mesenchymal Stem Cells (MSCs) into insulin-producing cells, the molecular mechanisms underlying its effect in the treatment of Type 1 Diabetes Mellitus (T1DM) is still not available. Objectives: The purpose of this study was to evaluate the effect of cultured MSCs on the surface of electrospun Poly-L-Lactide acid (PLLA) scaffolds coated with Matricaria chamomilla L. Oil in treatment of T1DM and clarify its possible mechanisms. Methods: The current experimental study was performed using a total number of 36 male New Zealand white rabbits in the Experimental Animal Unit of Shahid Beheshti University of Medical Sciences Tehran, Iran, in 2018. A rabbit model of T1DM was established through a single intraperitoneal injection of streptozotocin (STZ) (80 mg/kg body weight)-1 dissolved in 0. 2 mL of normal saline. For 21 days after implantation of cultured MSCs on the surface of electrospun PLLA scaffolds coatedwith Matricaria chamomilla L. Oil, blood glucose levels, plasma insulin levels, plasma and pancreatic Glucagon-Like Peptide 1 (GLP-1) were evaluated. Results: The STZ-treated rabbits exhibited decreased levels of blood glucose (P < 0. 01 vs. other groups except control), increased levels of plasma insulin (P < 0. 01 vs. other groups except control), plasma and pancreatic GLP-1 (P < 0. 001 vs. control, and P < 0. 05 vs. other groups except control) at 21 days after implantation of cultured MSCs on the surface of electrospun PLLA scaffolds coated with Matricaria chamomilla L. Oil. Conclusions: Collectively, our finding showed the presence of Matricaria chamomilla L. Oil might improve survival and differentiation MSCs in Insulin Producing Cells that can be attributed to antioxidant properties of its bioactive compounds.

Cites

The Effect of Combination Therapy (Thermal Therapy and Oxymel) on Insulin Resistance and Langerhans Islands in Diabetic Rats

References

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APA: Copy

Saghahazrati, Saeid, KOBARFARD, FARZAD, & MINAEI, BAGHER. (2019). The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(2), 0-0. SID. https://sid.ir/paper/293867/en

Vancouver: Copy

Saghahazrati Saeid, KOBARFARD FARZAD, MINAEI BAGHER. The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(2):0-0. Available from: https://sid.ir/paper/293867/en

IEEE: Copy

Saeid Saghahazrati, FARZAD KOBARFARD, and BAGHER MINAEI, “The Protective Effects of Cultured Mesenchymal Stem Cells onto the Surface of Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria Chamomilla L. Oil in Streptozotocin-Induced Diabetic Rabbits,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 2, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/293867/en

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