THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (ANP) ON SPONTANEOUS ACTIVITY OF RAT UTERUS SMOOTH MUSCLE CELLS

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BABAEE P.; HAEERY A.; FAJRAK H.; KHOUSHBATEN A.

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Journal: Hakim Journal Year:2000 | Volume:3 | Issue:2 Page(s): 109-116

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Title

THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (ANP) ON SPONTANEOUS ACTIVITY OF RAT UTERUS SMOOTH MUSCLE CELLS

Author(s)

BABAEE P. | HAEERY A. | FAJRAK H. | KHOUSHBATEN A. | Issue Writer Certificate

Keywords

ATRIAL NATRIURETIC PEPTIDE (ANP)Q4

SMOOTH MUSCLEQ4

UTERUSQ4

Abstract

In this study, we used In vitro experiments on virgin female rats weighing between 180-200 gr. Rats uterine horns were separated and studied using isolated muscle preparation. In this study, the effects of synthetic analogue of ANP (Atriopeptin II) were tested on spontaneous activity of UTERUS in presence of different conditions such as, oestrus cycle; dioestrus cycle, estrogen, pre-treated, progesterone pre-treated, overectomized and overectomized with pre-treatment of oestrogen. APII revealed a significant relaxation effect both on UTERUS in oestrus cycle and estrogen pretreated UTERUS but showed very small effect on progesterone pre-treated tissues and UTERUS in the dioestrus phase. APII reduced both amplitude and frequency of UTERUS spontaneous contractions. UTERUS contractions by oxytocin were diminished by APII dose dependently. The APII relaxation effect on the UTERUS was diminished in overectomized rats, and this reduction was restored by estrogen. The results show that APII analogue of ANP has much more relaxation effects in presence of estrogen however, progesterone is a factor, which that, antagonized this response.

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APA: Copy

BABAEE, P., HAEERY, A., FAJRAK, H., & KHOUSHBATEN, A.. (2000). THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (ANP) ON SPONTANEOUS ACTIVITY OF RAT UTERUS SMOOTH MUSCLE CELLS. HAKIM RESEARCH JOURNAL, 3(2), 109-116. SID. https://sid.ir/paper/29455/en

Vancouver: Copy

BABAEE P., HAEERY A., FAJRAK H., KHOUSHBATEN A.. THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (ANP) ON SPONTANEOUS ACTIVITY OF RAT UTERUS SMOOTH MUSCLE CELLS. HAKIM RESEARCH JOURNAL[Internet]. 2000;3(2):109-116. Available from: https://sid.ir/paper/29455/en

IEEE: Copy

P. BABAEE, A. HAEERY, H. FAJRAK, and A. KHOUSHBATEN, “THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE (ANP) ON SPONTANEOUS ACTIVITY OF RAT UTERUS SMOOTH MUSCLE CELLS,” HAKIM RESEARCH JOURNAL, vol. 3, no. 2, pp. 109–116, 2000, [Online]. Available: https://sid.ir/paper/29455/en

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