Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Mirabutalebi Seyed Hamidreza; Karami Noorodin; ASHRAFZADEH HAMID REZA; Akhvansales Zhima; TAVAKOLI MARYAM; GHASEMI NASRIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2018 | Volume:16 | Issue:9 Page(s): 571-576

Download Full-Text

View:

254

Download:

108

Cites:

Information Journal Paper

Title

Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study

Author(s)

Keywords

In vitro fertilization

Mitochondria

Mutation

Cell aging

Abstract

Background: The quality of oocyte is often considered as a limiting factor for fertility, especially IVF. Some Mitochondrial Mutations, particularly the 4977-bp deletion increase with the age. Thus, this Mutation can serve as a marker for Cell aging, which indicates the reduced quality of the oocytes for fertilization. It has been suggested that this can also be investigated in the blood cells of women with IVF failure. Objective: 1-Determination of the frequency of 4977-bp deletion in women with IVF failure, 2-Investigation of the relationship between 4977-bp deletion and the age of patients. Materials and Methods: Polymerase chain reaction was used to detect the 4977-bp deletion in blood samples of 52 IVF failure women and 52 women who had at least one healthy child. After polymerase chain reaction with deleted and wild-type primers, the products were examined using agarose gel electrophoresis. Results: 48. 07% of women with IVF failure and 34. 62% of healthy women had a Mitochondrial 4977-bp deletion, with p=0. 163 and OR: 1. 749. Also, in association with the age of these patients and the frequency of 4977-bp Mutation, p and OR were obtained 0. 163 and 1. 749, respectively and frequency of this Mutation was higher in patients over 35 yr old compared to other subgroups (Patients ≥ 35: 57. 69). Conclusion: According to the findings of this study, there is no a significant relationship between the frequency of Mitochondrial 4977-bp Mutation and failure in IVF.

Cites

No record.

References

Cite

APA: Copy

Mirabutalebi, Seyed Hamidreza, Karami, Noorodin, ASHRAFZADEH, HAMID REZA, Akhvansales, Zhima, TAVAKOLI, MARYAM, & GHASEMI, NASRIN. (2018). Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 16(9), 571-576. SID. https://sid.ir/paper/296536/en

Vancouver: Copy

Mirabutalebi Seyed Hamidreza, Karami Noorodin, ASHRAFZADEH HAMID REZA, Akhvansales Zhima, TAVAKOLI MARYAM, GHASEMI NASRIN. Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2018;16(9):571-576. Available from: https://sid.ir/paper/296536/en

IEEE: Copy

Seyed Hamidreza Mirabutalebi, Noorodin Karami, HAMID REZA ASHRAFZADEH, Zhima Akhvansales, MARYAM TAVAKOLI, and NASRIN GHASEMI, “Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 16, no. 9, pp. 571–576, 2018, [Online]. Available: https://sid.ir/paper/296536/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops