INTERLEUKIN-17 GENE EXPRESSION AND SERUM LEVELS IN ACUTE REJECTED AND NON-REJECTED LIVER TRANSPLANT PATIENTS

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AFSHARI AFSOON; YAGHOBI RAMIN; KARIMI MOHAMMAD HOSSEIN; DARBOOIE MOJTABA; AZARPIRA NEGAR

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Journal: IRANIAN JOURNAL OF IMMUNOLOGY Year:2014 | Volume:11 | Issue:1 Page(s): 29-39

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Title

INTERLEUKIN-17 GENE EXPRESSION AND SERUM LEVELS IN ACUTE REJECTED AND NON-REJECTED LIVER TRANSPLANT PATIENTS

Author(s)

Keywords

ACUTE REJECTION

INTERLUKIN-17

LIVER TRANSPLANTATION

Abstract

Background: Interleukin-17 (IL-17), as a potent proinflammatory cytokine, has a critical role in post liver transplant outcomes. However, there is not much information about the effects of IL-17 cytokine on acute liver rejection.Objective: To evaluate the role of IL-17 in post-liver transplant acute rejection.Methods: Ninety seven adult liver transplant patients who enrolled in this cross sectional study were divided into Non-Acute Rejected (Non-AR) and Acute Rejected (AR) patient groups. Three blood samples were collected from each patient in days 1, 4 and 7 post liver transplantation. The IL-17 mRNA levels were evaluated using an in-house real time PCR protocol. IL-17 protein levels were also analyzed in Non-AR, AR and also control groups using ELISA method.Results: The IL-17 mRNA expression level continuously increased in AR patients in all days of follow-up post liver transplantation. IL-17 expression was, however, down regulated after day 4 post-transplant follow-up in Non-AR patients. Both IL-17 mRNA expression and protein levels were also significantly increased in AR patients compared with Non-AR ones.Conclusion: Based on these findings, significant increase of IL-17 mRNA and protein levels in AR patients highlights the important role of IL-17 in acute liver rejection.

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APA: Copy

AFSHARI, AFSOON, YAGHOBI, RAMIN, KARIMI, MOHAMMAD HOSSEIN, DARBOOIE, MOJTABA, & AZARPIRA, NEGAR. (2014). INTERLEUKIN-17 GENE EXPRESSION AND SERUM LEVELS IN ACUTE REJECTED AND NON-REJECTED LIVER TRANSPLANT PATIENTS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI), 11(1), 29-39. SID. https://sid.ir/paper/296861/en

Vancouver: Copy

AFSHARI AFSOON, YAGHOBI RAMIN, KARIMI MOHAMMAD HOSSEIN, DARBOOIE MOJTABA, AZARPIRA NEGAR. INTERLEUKIN-17 GENE EXPRESSION AND SERUM LEVELS IN ACUTE REJECTED AND NON-REJECTED LIVER TRANSPLANT PATIENTS. IRANIAN JOURNAL OF IMMUNOLOGY (IJI)[Internet]. 2014;11(1):29-39. Available from: https://sid.ir/paper/296861/en

IEEE: Copy

AFSOON AFSHARI, RAMIN YAGHOBI, MOHAMMAD HOSSEIN KARIMI, MOJTABA DARBOOIE, and NEGAR AZARPIRA, “INTERLEUKIN-17 GENE EXPRESSION AND SERUM LEVELS IN ACUTE REJECTED AND NON-REJECTED LIVER TRANSPLANT PATIENTS,” IRANIAN JOURNAL OF IMMUNOLOGY (IJI), vol. 11, no. 1, pp. 29–39, 2014, [Online]. Available: https://sid.ir/paper/296861/en

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