EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS

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MOHAMED ESSA M.M.; SUBRAMANIAN P.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2007 | Volume:6 | Issue:2 Page(s): 119-123

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Title

EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS

Author(s)

MOHAMED ESSA M.M. | SUBRAMANIAN P. | Issue Writer Certificate

Keywords

HYPERAMMONEMIA

PONGAMIA PINNATA

CIRCADIAN

LIPID PEROXIDATION

ANTIOXIDANTS

Abstract

Effects of PONGAMIA PINNATA, an indigenous plant used in Ayurvedic Medicine in India on the temporal variations of circulatory LIPID PEROXIDATION products and ANTIOXIDANTS in ammonium chloride-(AC)-induced hyperammonemic rats has been studied. Experimental rats were divided into control, AC-treated, those treated with AC + ethanolic leaf extract of P. pinnata (PPEt), and PPEt-treated. The characteristics of 24 h rhythms (acrophase, amplitude and mesor) of LIPID PEROXIDATION products (thiobarbituric acid reactive sub stances - TBARS) and ANTIOXIDANTS (reduced glutathione (GSH), glutathione peroxidase (GPx), superox ide dismutase (SOD) and catalase (CAT)) were analyzed. Elevated LIPID PEROXIDATION (increased mesor of TBARS) associated with decreased activities of ANTIOXIDANTS (decreased mesor of GPx, GSH, SOD and CAT) were found in hyperammonemic rats. Differences were also found in amplitude and 'r' values between the hyperammonemic rats and other experimental groups. These alterations clearly indicate that temporal redox status could be modulated by PPEt during hyperammonemic conditions, which may also play a crucial role in disease development.

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APA: Copy

MOHAMED ESSA, M.M., & SUBRAMANIAN, P.. (2007). EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 6(2), 119-123. SID. https://sid.ir/paper/297161/en

Vancouver: Copy

MOHAMED ESSA M.M., SUBRAMANIAN P.. EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2007;6(2):119-123. Available from: https://sid.ir/paper/297161/en

IEEE: Copy

M.M. MOHAMED ESSA, and P. SUBRAMANIAN, “EFFECTS OF PONGAMIA PINNATA ON LIPID PEROXIDATION PRODUCTS AND ANTIOXIDANTS IN HYPERAMMONEMIC RATS: WITH REFERENCE TO CIRCADIAN VARIATIONS,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 6, no. 2, pp. 119–123, 2007, [Online]. Available: https://sid.ir/paper/297161/en

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