STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN

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ASHRAFUL ALAM MD.; ABDUL AWAL MD.; SUBHAN N.; SIKDER M.H.; MAHBUBUL ALAM S.M.; MOSTOFA M.; UDDIN SH.J.

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Journal: IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) Year:2008 | Volume:7 | Issue:1 Page(s): 1-8

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Title

STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN

Author(s)

Keywords

EQUILIBRIUM DIALYSIS

AMLODIPINE

ASSOCIATION CONSTANT

BINDING SITE

ARSENIC-AMLODIPINE INTERACTION

CALCIUM CHANNEL BLOCKERS

Abstract

In this study, the binding of AMLODIPINE (a Calcium channel Blocker) and arsenic (metalloid) to bovine serum albumin (BSA) was studied by EQUILIBRIUM DIALYSIS(ED) method in order to have an insight into their binding chemistry to BSA. Free AMLODIPINE concentration was increased due to addition of arsenic which reduced the binding of the compounds to BSA. However, the free fraction was not increased to a level as it was expected from direct competitive displacement. The free AMLODIPINE concentration was increased according to increasing the AMLODIPINE concentration when only the BSA was present. When the BINDING SITEs were blocked by sufficient amount of arsenic, the increment of free concentration of AMLODIPINE was prominent. When no arsenic was added, the free concentration of AMLODIPINE was only 6.6% to 10.3%; whereas this release was 7.65% to 13.65% when arsenic was added with an increasing concentration from 1x10-5M to 12x10-5M. This suggests that in the presence of arsenic, the AMLODIPINE is slowly displaced from its high affinity BINDING SITE.

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APA: Copy

ASHRAFUL ALAM, MD., ABDUL AWAL, MD., SUBHAN, N., SIKDER, M.H., MAHBUBUL ALAM, S.M., MOSTOFA, M., & UDDIN, SH.J.. (2008). STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 1-8. SID. https://sid.ir/paper/297166/en

Vancouver: Copy

ASHRAFUL ALAM MD., ABDUL AWAL MD., SUBHAN N., SIKDER M.H., MAHBUBUL ALAM S.M., MOSTOFA M., UDDIN SH.J.. STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):1-8. Available from: https://sid.ir/paper/297166/en

IEEE: Copy

MD. ASHRAFUL ALAM, MD. ABDUL AWAL, N. SUBHAN, M.H. SIKDER, S.M. MAHBUBUL ALAM, M. MOSTOFA, and SH.J. UDDIN, “STUDIES OF IN-VITRO AMLODIPINE AND ARSENIC DISPLACEMENT INTERACTION AT BINDING SITES OF BOVINE SERUM ALBUMIN,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 1–8, 2008, [Online]. Available: https://sid.ir/paper/297166/en

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