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Information Journal Paper

Title

HEPATOPROTECTIVE ACTIVITY OF CAMELLIA SINENSIS AND ITS POSSIBLE MECHANISM OF ACTION

Pages

  9-14

Abstract

 The present study appraised the HEPATOPROTECTIVE activity of aqueous extract of CAMELLIA SINENSIS leaves and its possible mechanism of action. Liver damage was induced by intraperitoneal administration of car bon tetrachloride/olive oil (50 % v/v, 0.5 ml/kg ) in male Wistar rats (150-220g) once daily for 7 days and the extent of damage was studied by assessing biochemical parameters such as alanine amino trans ferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total protein and albumin in serum and concentrations of lipid peroxides (LPO), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in liver. The aqueous extract of CAMELLIA SINENSIS (100 mg and 200 mg/Kg) were ad ministered orally to the animals with hepatotoxicity induced by CARBON TETRACHLORIDE and its effects on bio chemical parameters were compared with those in animals treated with vitamin E (100 mg/Kg). Histopa thological studies were also done. CAMELLIA SINENSIS 100 and 200mg/kg results in significant reduction in serum hepatic enzymes and liver lipid peroxide which were increased by CARBON TETRACHLORIDE. There was significant increase in serum total protein, albumin and liver GSH, SOD and CAT when compared to those in rats treated by CARBON TETRACHLORIDE. The ANTIOXIDANT activity of CAMELLIA SINENSIS (100 and 200mg/Kg) were comparable with the effects of vitamin E (100mg/Kg). Histopathological changes (con gestion of central vein, centrilobular necrosis and sinusoidal congestion) induced by CARBON TETRACHLORIDE were reduced to a moderate extent in Camellia-sinensis-treated rats. Taking together, CAMELLIA SINENSIS protectes the liver from carbon-tetrachloride-induced damage. Probable mechanism of its action is its anti-oxidant property.

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    APA: Copy

    SENGOTTUVELU, S., DURAISAMI, S., NANDHAKUMAR, J., DURAISAMI, R., & VASUDEVAN, M.. (2008). HEPATOPROTECTIVE ACTIVITY OF CAMELLIA SINENSIS AND ITS POSSIBLE MECHANISM OF ACTION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), 7(1), 9-14. SID. https://sid.ir/paper/297167/en

    Vancouver: Copy

    SENGOTTUVELU S., DURAISAMI S., NANDHAKUMAR J., DURAISAMI R., VASUDEVAN M.. HEPATOPROTECTIVE ACTIVITY OF CAMELLIA SINENSIS AND ITS POSSIBLE MECHANISM OF ACTION. IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT)[Internet]. 2008;7(1):9-14. Available from: https://sid.ir/paper/297167/en

    IEEE: Copy

    S. SENGOTTUVELU, S. DURAISAMI, J. NANDHAKUMAR, R. DURAISAMI, and M. VASUDEVAN, “HEPATOPROTECTIVE ACTIVITY OF CAMELLIA SINENSIS AND ITS POSSIBLE MECHANISM OF ACTION,” IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT), vol. 7, no. 1, pp. 9–14, 2008, [Online]. Available: https://sid.ir/paper/297167/en

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