EFFECTS OF 2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM

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HADIZADEHA F.; ANARAKI FIROOZ B.F.; TAQVI S.E.H.

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2005 | Volume:1 | Issue:1 Page(s): 27-31

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Title

EFFECTS OF 2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM

Author(s)

HADIZADEHA F. | ANARAKI FIROOZ B.F. | TAQVI S.E.H. | Issue Writer Certificate

Keywords

2-DIMETHYLAMINO-SUBSTITUTED DIHYDROPYRIDINES

RABBIT JEJUNUM

CALCIUM CHANNEL

Abstract

In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethylamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicarboxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicarboxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds. Some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-K+ contracted tissues were relaxed partially.

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APA: Copy

HADIZADEHA, F., ANARAKI FIROOZ, B.F., & TAQVI, S.E.H.. (2005). EFFECTS OF 2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1(1), 27-31. SID. https://sid.ir/paper/300173/en

Vancouver: Copy

HADIZADEHA F., ANARAKI FIROOZ B.F., TAQVI S.E.H.. EFFECTS OF 2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2005;1(1):27-31. Available from: https://sid.ir/paper/300173/en

IEEE: Copy

F. HADIZADEHA, B.F. ANARAKI FIROOZ, and S.E.H. TAQVI, “EFFECTS OF 2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 1, no. 1, pp. 27–31, 2005, [Online]. Available: https://sid.ir/paper/300173/en

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