MULTIPLE LINEAR REGRESSION STUDY OF 2,4-DISUBSTITUTED 1,5- BENZODIAZEPINE AS POTENTIAL ANTIINFECTIVES

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SUDESH BHATIA MANISH; BALKRISHNA CHOUDHARI PRAFULLA; BHANUDAS INGALE KUNDAN

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Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2010 | Volume:6 | Issue:3 Page(s): 199-208

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Title

MULTIPLE LINEAR REGRESSION STUDY OF 2,4-DISUBSTITUTED 1,5- BENZODIAZEPINE AS POTENTIAL ANTIINFECTIVES

Author(s)

SUDESH BHATIA MANISH | BALKRISHNA CHOUDHARI PRAFULLA | BHANUDAS INGALE KUNDAN | Issue Writer Certificate

Keywords

ANTIBACTERIAL

5-BENZODIAZEPINE

3D-QSAR

MULTIPLE LINEAR REGRESSION

Abstract

This paper describes 3D-QSAR analysis and biological evaluation of 1, 5- benzodiazepine analogues. Benzodiazepine nucleus with its simple structure gives a good opportunity for further modification regarding an increase of its antimicrobial activity.We synthesized a series of benzodiazepine analogues from condensation of various chalcones and halo substituted o-phenelynene diamines. All compounds were assayed in vitro against, E. coli, P. aeruginosa, S. aureus. The models were generated on the Vlife MDS 3.5; selected models showed a correlation coefficient (r2) above 0.9 with cross-validated correlation coefficient (q2) above 0.8, respectively, for all the selected organisms. The 3D-QSAR models generated were externally validated for all models using a test set of 6 molecules for which the predictive r 2 (r2 -pred) was found to be above 0.45. The results of 3D-QSAR indicate that contours can be used to design some potent antibacterial agents.

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APA: Copy

SUDESH, BHATIA MANISH, BALKRISHNA, CHOUDHARI PRAFULLA, & BHANUDAS, INGALE KUNDAN. (2010). MULTIPLE LINEAR REGRESSION STUDY OF 2,4-DISUBSTITUTED 1,5- BENZODIAZEPINE AS POTENTIAL ANTIINFECTIVES. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 6(3), 199-208. SID. https://sid.ir/paper/300263/en

Vancouver: Copy

SUDESH BHATIA MANISH, BALKRISHNA CHOUDHARI PRAFULLA, BHANUDAS INGALE KUNDAN. MULTIPLE LINEAR REGRESSION STUDY OF 2,4-DISUBSTITUTED 1,5- BENZODIAZEPINE AS POTENTIAL ANTIINFECTIVES. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2010;6(3):199-208. Available from: https://sid.ir/paper/300263/en

IEEE: Copy

BHATIA MANISH SUDESH, CHOUDHARI PRAFULLA BALKRISHNA, and INGALE KUNDAN BHANUDAS, “MULTIPLE LINEAR REGRESSION STUDY OF 2,4-DISUBSTITUTED 1,5- BENZODIAZEPINE AS POTENTIAL ANTIINFECTIVES,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 6, no. 3, pp. 199–208, 2010, [Online]. Available: https://sid.ir/paper/300263/en

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