HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF SERTRALINE IN HUMAN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARSHCHI AMIR; GHIASI GOLBARG; BAHRAMI GHOLAMREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Sciences Year:2009 | Volume:5 | Issue:3 Page(s): 171-178

Download Full-Text

View:

344

Download:

Cites:

Information Journal Paper

Title

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF SERTRALINE IN HUMAN

Author(s)

FARSHCHI AMIR | GHIASI GOLBARG | BAHRAMI GHOLAMREZA | Issue Writer Certificate

Keywords

4-CHLORO-7-NITROBENZOFURAZAN

DETERMINATION

HPLC

SERTRALINE

Abstract

An accurate and sensitive reversed-phase high-performance liquid chromatographic method for DETERMINATION of SERTRALINE in human serum is described using 4-CHLORO-7-NITROBENZOFURAZAN as pre-column derivatization agent. The drug and an internal standard (azithrimycin) were extracted from serum using a mixture of diethyl ether-chloroform and subjected to the pre-column derivatization with the reagent. Analysis of the resulted derivatives was performed on a Lichrosorb CN (250×4.0 mm) column using a mobile phase composed of methanol and sodium phosphate buffer (0.05 M; pH 3.7) containing 2 ml/lit triethylamine (63:37 v/v). Detector response was monitored at excitation and emission wavelengths of 470 and 537 nm, respectively. The calibration curve was linear over the concentration range of 2 to 640 ng/ml. The lower limits of detection and quantification were 0.5 and 2 ng/ml, respectively. The validation of the analysis was carried out in terms of specificity, sensitivity, linearity, precision, accuracy and stability. The validated method was shown to be accurate, with intra-day and inter-day accuracy from 0.3 to 4.2% and precise, with intra-day and inter-day precision from 2.4 to 15.5%. The drug is detected at concentrations as low as 2 ng/ml in a 0.5 ml serum sample and the described method can be easily applied in human single-dose pharmacokinetic studies of SERTRALINE.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

FARSHCHI, AMIR, GHIASI, GOLBARG, & BAHRAMI, GHOLAMREZA. (2009). HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF SERTRALINE IN HUMAN. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 5(3), 171-178. SID. https://sid.ir/paper/300292/en

Vancouver: Copy

FARSHCHI AMIR, GHIASI GOLBARG, BAHRAMI GHOLAMREZA. HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF SERTRALINE IN HUMAN. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2009;5(3):171-178. Available from: https://sid.ir/paper/300292/en

IEEE: Copy

AMIR FARSHCHI, GOLBARG GHIASI, and GHOLAMREZA BAHRAMI, “HIGH PERFORMANCE LIQUID CHROMATOGRAPHY DETERMINATION OF SERTRALINE IN HUMAN,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 5, no. 3, pp. 171–178, 2009, [Online]. Available: https://sid.ir/paper/300292/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops