THE EFFECT OF SILYMARIN ON MEMORY AND LEARNING DISORDERS INDUCED BY TIO2 NANOPARTICLES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAHRAM KALHORI PARASTU; HAJIZADEH MOGHADDAM AKBAR; Zare Mahboobeh; SAYRAFI REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DANESHVAR MEDICINE Year:2018 | Volume:25 | Issue:132 Page(s): 39-44

Download Full-Text

Persian Verion

View:

820

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF SILYMARIN ON MEMORY AND LEARNING DISORDERS INDUCED BY TIO2 NANOPARTICLES

Author(s)

BAHRAM KALHORI PARASTU | HAJIZADEH MOGHADDAM AKBAR | Zare Mahboobeh | SAYRAFI REZA | Issue Writer Certificate

Keywords

TIO2 NANOPARTICLESQ1

HIPPOCAMPUSQ2

PASSIVE AVOIDANCE LEARNINGQ2

SILYMARINQ2

Abstract

Background and Objective: Titanium dioxide nanoparticles (NP Tio2) are one of the most highly used particles in the world. They are used for biomedical and cosmetic goals. Several studies have shown that NP Tio2 induce oxidative stress in the HIPPOCAMPUS. SILYMARIN is a flavenolignan that is gained from seed of milk thistle (Silybum marianum) and due to its inhibition of free radicals, acts as an antioxidant in central nerves system. Aim of this research was to study the effect of SILYMARIN on memory and learning disorders induced by TIO2 NANOPARTICLES.Materials and Methods: In this experimental study, rats were divided into four groups: control, vehicle, toxic group (150 mg/kg of TiO2 NPs for three weeks orally) as well as SILYMARIN (100 mg/kg for three weeks orally after TiO2 NPs administration). The destructive effect of Nano TiO2 and treatment with SILYMARIN were measured by passive avoidance test using shuttle box.Results: Oral administration of Tio2 NPs resulted in a significant increase of time of spending in dark box and reduction of time to enter the dark box and SILYMARIN significantly decreased time of spending in dark box (P>0.001) and treatment with SILYMARIN returned the index to the level of control (P>0.001).Conclusion: The results from the present study indicated that SILYMARIN probably due to its antioxidant effects causes improvement of memory and learning disorders induced by TIO2 NANOPARTICLES.

Cites

No record.

References

Cite

APA: Copy

BAHRAM KALHORI, PARASTU, HAJIZADEH MOGHADDAM, AKBAR, Zare, Mahboobeh, & SAYRAFI, REZA. (2018). THE EFFECT OF SILYMARIN ON MEMORY AND LEARNING DISORDERS INDUCED BY TIO2 NANOPARTICLES. DANESHVAR MEDICINE, 25(132 ), 39-44. SID. https://sid.ir/paper/30360/en

Vancouver: Copy

BAHRAM KALHORI PARASTU, HAJIZADEH MOGHADDAM AKBAR, Zare Mahboobeh, SAYRAFI REZA. THE EFFECT OF SILYMARIN ON MEMORY AND LEARNING DISORDERS INDUCED BY TIO2 NANOPARTICLES. DANESHVAR MEDICINE[Internet]. 2018;25(132 ):39-44. Available from: https://sid.ir/paper/30360/en

IEEE: Copy

PARASTU BAHRAM KALHORI, AKBAR HAJIZADEH MOGHADDAM, Mahboobeh Zare, and REZA SAYRAFI, “THE EFFECT OF SILYMARIN ON MEMORY AND LEARNING DISORDERS INDUCED BY TIO2 NANOPARTICLES,” DANESHVAR MEDICINE, vol. 25, no. 132 , pp. 39–44, 2018, [Online]. Available: https://sid.ir/paper/30360/en

Related Journal Papers