THE ROLE OF ADENOSINE RECEPTORS IN THE EXPRESSION OF MORPHINE-INUCED CONDITIONED PLACE PREFERENCE IN MICE

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SAHRAEI HEDAYAT; DARBANDI N.; HAERI ROUHANI SEYED ALI; SEPEHRI H.; GHOSHOUNI H.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2004 | Volume:11 | Issue:50 Page(s): 43-50

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Title

THE ROLE OF ADENOSINE RECEPTORS IN THE EXPRESSION OF MORPHINE-INUCED CONDITIONED PLACE PREFERENCE IN MICE

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Keywords

MORPHINEQ2

ADENOSINE SYSTEMQ4

CPPQ3

DRUG-DEPENDENCEQ3

Abstract

In the present study, the effects of adenosine receptor agonists and antagonists have been investigated on the expression of MORPHINE-induced conditioned place preference (CPP) in mice. Subcutaneous (s.c.) administration of different doses of MORPHINE (0.5-5 mg/kg) induced CPP dose-dependently. Intrapretoneal (i.p.) application of the adenosine receptor antagonist, theophyline (2.5, 5,10 mg/kg), 1 hour prior to testing, reduced the expression of CPP induced by MORPHINE in a dose independent manner. Intracereberoventricular injections (i.c.v.) of theophylline (0.015-0.005 µg/mice) also decreased MORPHINE-induced CPP. Adenosine, (1-10 mg/kg, 1 h before the test; ip.), decreased the effect of MORPHINE. The drug reduced MORPHINE effect when it used as i.c. v. (1 µg/mice). The adenosine Al receptor agonist N6-cyclohexyladenosine (CHA) when used systemically (0.01, 0.1, 0.25, 0.05-0.1mg/kg; ip.) or centrally(1-10µg/mice, i.c.v.) did not show any effect on the expression of MORPHINE-induced CPP. The Al receptor antagonist, 8-Phenyle Theophylline (8-PT) in different doses (2, 4, 6 and 8 mg/kg, ip.) did not show any effect on the expression of MORPHINE-induced CPP. In Conclusion it seems likely that adenosine receptors might be involved in the expression of MORPHINE-induced CPP and the effect is most likely to be via centralA2 adenosine receptors which is in accordance with the distribution of the receptors in rewarding brain area. Further experiments in this field must be done to clarify the exact role of the ADENOSINE SYSTEM on the MORPHINE reward.

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APA: Copy

SAHRAEI, HEDAYAT, DARBANDI, N., HAERI ROUHANI, SEYED ALI, SEPEHRI, H., & GHOSHOUNI, H.. (2004). THE ROLE OF ADENOSINE RECEPTORS IN THE EXPRESSION OF MORPHINE-INUCED CONDITIONED PLACE PREFERENCE IN MICE. DANESHVAR MEDICINE, 11(50), 43-50. SID. https://sid.ir/paper/30429/en

Vancouver: Copy

SAHRAEI HEDAYAT, DARBANDI N., HAERI ROUHANI SEYED ALI, SEPEHRI H., GHOSHOUNI H.. THE ROLE OF ADENOSINE RECEPTORS IN THE EXPRESSION OF MORPHINE-INUCED CONDITIONED PLACE PREFERENCE IN MICE. DANESHVAR MEDICINE[Internet]. 2004;11(50):43-50. Available from: https://sid.ir/paper/30429/en

IEEE: Copy

HEDAYAT SAHRAEI, N. DARBANDI, SEYED ALI HAERI ROUHANI, H. SEPEHRI, and H. GHOSHOUNI, “THE ROLE OF ADENOSINE RECEPTORS IN THE EXPRESSION OF MORPHINE-INUCED CONDITIONED PLACE PREFERENCE IN MICE,” DANESHVAR MEDICINE, vol. 11, no. 50, pp. 43–50, 2004, [Online]. Available: https://sid.ir/paper/30429/en

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