PHOTODYNAMIC THERAPY: A NEW APPROACH TO REMOVE EMBRYOS OF THE WISTAR RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NABIOUNI M.; MAJLES ARA M.H.; SHEYKH ALESLAMI AZAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2010 | Volume:4 | Issue:2 Page(s): 61-66

Download Full-Text

View:

350

Download:

211

Cites:

Information Journal Paper

Title

PHOTODYNAMIC THERAPY: A NEW APPROACH TO REMOVE EMBRYOS OF THE WISTAR RAT

Author(s)

NABIOUNI M. | MAJLES ARA M.H. | SHEYKH ALESLAMI AZAR | Issue Writer Certificate

Keywords

PHOTODYNAMIC THERAPY (PDT)

ECTOPIC PREGNANCY

EMBRYO

PLACENTA

FERTILITY

Abstract

Background: Photodynamic therapy (PDT) is a promising new cancer treatment strategy which inactivates tumor cells by simultaneoulsy using light and a photosensitizer. The similarity between tumors and newly implanted EMBRYOs is notable. Extrauterine pregnancy (EUP) does not have a definite treatment and previous therapeutic options (medical and surgical) have not been effective or suitable. Therefore, PDT is suggested as a possible treatment for EUP.Materials and Methods: The photosensitizer, hematoporphyrin, was injected locally into the PLACENTA of one selected EMBRYO from a pregnant Wistar rat (E15). Then, a laser beam was illuminated at the same point and 48 hours later, changes in the EMBRYO and PLACENTA were investigated. Furthermore, the integrity of the uterus was examined by macroscopic evaluation and sonographic images. Results: Sections obtained from treated and control groups demonstrated that the EMBRYO and PLACENTA were damaged in the PDT group, whereas the control ones were intact. Furthermore, macroscopic observations and sonographic images during the second parturition after treatment showed that the uterus was intact and FERTILITY was preserved. Conclusion: Successful ablation of the treated EMBRYO with no clear damage to the uterus attests to the success of this approach. The successful use of hematoporphyrin, as a first generation photosensitizer, should be further investigated for its possible clinical applications.

Cites

No record.

References

No record.

Cite

APA: Copy

NABIOUNI, M., MAJLES ARA, M.H., & SHEYKH ALESLAMI, AZAR. (2010). PHOTODYNAMIC THERAPY: A NEW APPROACH TO REMOVE EMBRYOS OF THE WISTAR RAT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 4(2), 61-66. SID. https://sid.ir/paper/304506/en

Vancouver: Copy

NABIOUNI M., MAJLES ARA M.H., SHEYKH ALESLAMI AZAR. PHOTODYNAMIC THERAPY: A NEW APPROACH TO REMOVE EMBRYOS OF THE WISTAR RAT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2010;4(2):61-66. Available from: https://sid.ir/paper/304506/en

IEEE: Copy

M. NABIOUNI, M.H. MAJLES ARA, and AZAR SHEYKH ALESLAMI, “PHOTODYNAMIC THERAPY: A NEW APPROACH TO REMOVE EMBRYOS OF THE WISTAR RAT,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 4, no. 2, pp. 61–66, 2010, [Online]. Available: https://sid.ir/paper/304506/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops