ANDROLOGY: P-7: ASSOCIATION OF GONAD FAILURE WITH SERUM INSULIN LEVEL

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FARAHMANDLOU N.; AHMADI R.; BALALI SH.

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Paper Information

Journal: International Journal of Fertility & Sterility Year:2010 | Volume:4 | Issue:SUPPLEMENT 1 (11TH CONGRESS ON REPRODUCTIVE BIOMEDICINE- 5TH ROYAN NURSING AND MIDWIFERY SYMPOSIUM) Page(s): 54-54

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Title

ANDROLOGY: P-7: ASSOCIATION OF GONAD FAILURE WITH SERUM INSULIN LEVEL

Author(s)

FARAHMANDLOU N. | AHMADI R. | BALALI SH.

Keywords

INSULIN

ORCHIDECTOMY

OVARIECTOMY

Abstract

Background: Serum INSULIN variations are occasionally observed in patients suffering infertility or gonad failure. The main purpose of the present study was to clarify the effects of gonadectomy and sex steroid hormone replacement on serum INSULIN level in rats. Materials and Methods: Male rats were divided into control, orchidectomized, and testosterone receiving orchidectomized animals. Female rats were also divided into control, ovariectomized, progesterone or estradiol receiving ovariectomized animals. Testosterone (50mg/kg/day) or progesterone (20 mg/kg/day) and estradiol (200μg/kg/ day) were injected intraperitineally or subcutaneously, respectively. The period of 4 weeks was considered for each experiment. After 4 weeks, serum INSULIN was measured and compared statistically between the groups (ANOVA).Results: In male rats, ORCHIDECTOMY caused to decreasing (p<0.001) but testosterone replacement resulted in increasing of serum INSULIN level (p<0.01). In female rats, OVARIECTOMY caused to decreasing of serum INSULIN (p<0.001) and estradiol replacement prohibited but progesterone replacement could not prohibit the decreasing of INSULIN secretion after OVARIECTOMY (p<0.001). Conclusion: our findings indicated that sex steroid hormones play a pivotal role in INSULIN secretion. Therefore, in patients suffering infertility or gonad failure caused by gonadal hormones disorders, INSULIN pathophysiology should be considered clinically.

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APA: Copy

FARAHMANDLOU, N., AHMADI, R., & BALALI, SH.. (2010). ANDROLOGY: P-7: ASSOCIATION OF GONAD FAILURE WITH SERUM INSULIN LEVEL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 4(SUPPLEMENT 1 (11TH CONGRESS ON REPRODUCTIVE BIOMEDICINE- 5TH ROYAN NURSING AND MIDWIFERY SYMPOSIUM)), 54-54. SID. https://sid.ir/paper/304550/en

Vancouver: Copy

FARAHMANDLOU N., AHMADI R., BALALI SH.. ANDROLOGY: P-7: ASSOCIATION OF GONAD FAILURE WITH SERUM INSULIN LEVEL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2010;4(SUPPLEMENT 1 (11TH CONGRESS ON REPRODUCTIVE BIOMEDICINE- 5TH ROYAN NURSING AND MIDWIFERY SYMPOSIUM)):54-54. Available from: https://sid.ir/paper/304550/en

IEEE: Copy

N. FARAHMANDLOU, R. AHMADI, and SH. BALALI, “ANDROLOGY: P-7: ASSOCIATION OF GONAD FAILURE WITH SERUM INSULIN LEVEL,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 4, no. SUPPLEMENT 1 (11TH CONGRESS ON REPRODUCTIVE BIOMEDICINE- 5TH ROYAN NURSING AND MIDWIFERY SYMPOSIUM), pp. 54–54, 2010, [Online]. Available: https://sid.ir/paper/304550/en

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