THE EFFECT OF ZINC'S CHELATOR ON CLOSTRIDIUM BOTULINUM TYPE A TOXIN ACTIVITY

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BEHZADIANNEZHAD GH.; ATAEE R.; RIAZI GH.; SATARI MORTEZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: DANESHVAR MEDICINE Year:2001 | Volume:8 | Issue:30 Page(s): 45-52

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Title

THE EFFECT OF ZINC'S CHELATOR ON CLOSTRIDIUM BOTULINUM TYPE A TOXIN ACTIVITY

Author(s)

BEHZADIANNEZHAD GH. | ATAEE R. | RIAZI GH. | SATARI MORTEZA | Issue Writer Certificate

Keywords

CLOSTRIDIUMQ4

ZINC'S CHELATORQ4

BOTULINUM NEUROTOXIN TYPE AQ4

Abstract

CLOSTRIDIUM botulinum type A produces a neurotoxin, which is Zinc protein, with endopeptidase activity. In recent years, Medical uses of type A neurotoxin has been approved by FDA (US Food and Drug Administration). It’s stability is one of the important factor in neurotoxin preparation, clinical uses, and storage. In this study, the role of Zinc concentration on production and biological activity (intera peritoneum injection in mice) of the type A botulinum neurotoxin was investigated. The Zinc concentration in the culture media with different pH value, was determined with Atomic absorption /flame measurements. The results showed that, glass container and pH value effectively alter neurotoxin activity. Based on the results, it suggests that Zinc concentrations of the culture media is important for production and toxicity of type A botulinum neurotoxin.

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APA: Copy

BEHZADIANNEZHAD, GH., ATAEE, R., RIAZI, GH., & SATARI, MORTEZA. (2001). THE EFFECT OF ZINC'S CHELATOR ON CLOSTRIDIUM BOTULINUM TYPE A TOXIN ACTIVITY. DANESHVAR MEDICINE, 8(30), 45-52. SID. https://sid.ir/paper/30490/en

Vancouver: Copy

BEHZADIANNEZHAD GH., ATAEE R., RIAZI GH., SATARI MORTEZA. THE EFFECT OF ZINC'S CHELATOR ON CLOSTRIDIUM BOTULINUM TYPE A TOXIN ACTIVITY. DANESHVAR MEDICINE[Internet]. 2001;8(30):45-52. Available from: https://sid.ir/paper/30490/en

IEEE: Copy

GH. BEHZADIANNEZHAD, R. ATAEE, GH. RIAZI, and MORTEZA SATARI, “THE EFFECT OF ZINC'S CHELATOR ON CLOSTRIDIUM BOTULINUM TYPE A TOXIN ACTIVITY,” DANESHVAR MEDICINE, vol. 8, no. 30, pp. 45–52, 2001, [Online]. Available: https://sid.ir/paper/30490/en

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