THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN

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ASGARI N.; AKBARI M.T.

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Journal Paper

Paper Information

Journal: INTERNATIONAL JOURNAL OF FERTILITY & STERILITY Year:2012 | Volume:6 | Issue:SUPPLEMENT 1 Page(s): 144-144

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Title

THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN

Author(s)

ASGARI N. | AKBARI M.T.

Keywords

APO E4 POLYMORPHISM

APOLIPOPROTEIN E

RECURRENT PREGNANCY LOSS

Abstract

Background: Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the Apo E gene have the highest risk for thrombosis, we evaluated the frequency of the Apo E4 genotype among women suffering from recurrent pregnancy loss.Materials and Methods: 81 women with a history of two or more consecutive spontaneous abortions were examined for their APO-E genotypes based on restriction fragment length polymorphism analysis of PCR amplified fragments including amino acid positions 112 and 158.The observed genotypes were compared with negative controls.Results: Women experiencing recurrent pregnancy loss had a significantly higher prevalence of Apo E3/4, E4/4 genotypes (19.75%) compared with control women (2.46%) (p=0.00001).Conclusion: Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss.

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APA: Copy

ASGARI, N., & AKBARI, M.T.. (2012). THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 144-144. SID. https://sid.ir/paper/305140/en

Vancouver: Copy

ASGARI N., AKBARI M.T.. THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2012;6(SUPPLEMENT 1):144-144. Available from: https://sid.ir/paper/305140/en

IEEE: Copy

N. ASGARI, and M.T. AKBARI, “THE ASSOCIATION OF APOPROTIEN E POLYMORPHISMS WITH RECURRENT MISCARRIAGE IN IRANIAN WOMEN,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 6, no. SUPPLEMENT 1, pp. 144–144, 2012, [Online]. Available: https://sid.ir/paper/305140/en

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