THE STATE OF PERIPHERAL BLOOD NATURAL KILLER CELLS AND CYTOTOXICITYIN WOMEN WITH RECURRENT PREGNANCY LOSS AND UNEXPLAINEDINFERTILITY

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AZARGOON AZAM; MIRRASOULI YASAMAN; SHOKROLLAHI BAROUGH MAHDIEH; Barati Mehdi; KOKHAEI PARVIZ

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Journal Paper

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Journal: International Journal of Fertility & Sterility Year:2019 | Volume:13 | Issue:1 Page(s): 12-17

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Title

THE STATE OF PERIPHERAL BLOOD NATURAL KILLER CELLS AND CYTOTOXICITYIN WOMEN WITH RECURRENT PREGNANCY LOSS AND UNEXPLAINEDINFERTILITY

Author(s)

Keywords

CD56++

INFERTILITY

PERFORIN

PERIPHERAL NATURAL KILLER CELL

RECURRENT MISCARRIAGE

Abstract

Background: The prognostic value of peripheral natural killer (pNK) cells, as a screening test in women with recurrentpregnancy loss (RPL) and unexplained INFERTILITY, is still a matter for discussion. The purpose of this study was tocompare the percentage of circulating CD56++NK cells, CD69 and PERFORIN markers between women with unexplainedinfertility and RPL with the healthy control group. Materials and Methods: In this case-control study, the percentage of CD56++NK cells and activation markers (CD69and PERFORIN levels) in the peripheral blood were measured in 25 women with unexplained INFERTILITY, 24 women withidiopathic RPL and 26 women from the healthy control group, using specific monoclonal antibodies by flow cytometry. Results: The percentage of CD56++NK cells was significantly higher in patients with INFERTILITY in comparison withthe healthy control group (P=0. 007). There were not significant differences either in the total number of CD56++ cellsbetween the RPL group and the control group (P=0. 2) or between the RPL group and the infertile group (P=0. 36). The percentage of CD69+ lymphocytes in RPL group was significantly higher than in the INFERTILITY group (P=0. 004). There was a statistically significant difference in PERFORIN levels between RLP and control (P=0. 001) as well as RPLand infertile (P=0. 002) groups. Conclusion: An increased percentage of CD56++NK cells in patients with unexplained INFERTILITY, an elevated expressionof CD69 on NK cells in patients with RPL and INFERTILITY and a high level of PERFORIN on CD56++ cells in the RPL groupmight be considered as immunological risk factors in these women.

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APA: Copy

AZARGOON, AZAM, MIRRASOULI, YASAMAN, SHOKROLLAHI BAROUGH, MAHDIEH, Barati, Mehdi, & KOKHAEI, PARVIZ. (2019). THE STATE OF PERIPHERAL BLOOD NATURAL KILLER CELLS AND CYTOTOXICITYIN WOMEN WITH RECURRENT PREGNANCY LOSS AND UNEXPLAINEDINFERTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 12-17. SID. https://sid.ir/paper/306021/en

Vancouver: Copy

AZARGOON AZAM, MIRRASOULI YASAMAN, SHOKROLLAHI BAROUGH MAHDIEH, Barati Mehdi, KOKHAEI PARVIZ. THE STATE OF PERIPHERAL BLOOD NATURAL KILLER CELLS AND CYTOTOXICITYIN WOMEN WITH RECURRENT PREGNANCY LOSS AND UNEXPLAINEDINFERTILITY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):12-17. Available from: https://sid.ir/paper/306021/en

IEEE: Copy

AZAM AZARGOON, YASAMAN MIRRASOULI, MAHDIEH SHOKROLLAHI BAROUGH, Mehdi Barati, and PARVIZ KOKHAEI, “THE STATE OF PERIPHERAL BLOOD NATURAL KILLER CELLS AND CYTOTOXICITYIN WOMEN WITH RECURRENT PREGNANCY LOSS AND UNEXPLAINEDINFERTILITY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 12–17, 2019, [Online]. Available: https://sid.ir/paper/306021/en

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