The effect of hydroalcoholic extract of Ruta graveolens on oxidative stress markers and cholinesterase in brain rats receiving highcholesterol diet

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Bolouki Elham; Naderi Gholamali; ROGHANI MEHRDAD; ZAHEDI ELHAM

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Journal: DANESHVAR MEDICINE Year:2019 | Volume:26 | Issue:139 Page(s): 41-50

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Title

The effect of hydroalcoholic extract of Ruta graveolens on oxidative stress markers and cholinesterase in brain rats receiving highcholesterol diet

Author(s)

Bolouki Elham | Naderi Gholamali | ROGHANI MEHRDAD | ZAHEDI ELHAM | Issue Writer Certificate

Keywords

High-cholesterol dietQ1

Ruta graveolensQ2

Oxidative stressQ2

HippocampusQ2

ButyrylcholinesterasQ1

Abstract

Background and Objective: High cholesterol is associated with higher incidence of cardiovascular diseases and Oxidative stress. Ruta graveolens (RG) is one of the medicinal plants used in Iranian traditional medicine and different nations in the treatment of many diseases with antioxidant effects. The aim of this study was to investigate the effect of hydroalcoholic extract of RG on Oxidative stress markers and cholinesterase enzyme in brain tissue of rats receiving high-cholesterol (HC) diet. Materials and Methods: In this experimental study, 28 male Wistar rats were randomly divided into 4 groups: Control, RG and HC diet and HC diet+RG. For 8 weeks, Control and RG group received normal diet and the other 2 groups received HC diet (1% cholesterol and colic acid 0. 25%). After 8 weeks, treatment groups were treated with 100 mg/kg of RG intraperitoneally for 3 weeks. At the end of the experiment, the rats were anesthetized with diethyl ether and their brain were excised. After tissue homogenate was prepared, Oxidative stress markers (level of reactive oxygen species (ROS), glutathione and catalase activity) and Butyrylcholinesterase activity were measured using specific kits. Results: Eight-week diet with HC decreased glutathione level and the activity of Butyrylcholinesterase and catalase enzymes and increased ROS in the hippocampal tissue of rats. Three-week treatment with hydroalcoholic extract of RG significantly increased the activity of the Butyrylcholinesterase enzyme in the treated rats compared with the HC diet group. In addition, the activity of catalase and level of glutathione increased in HC diet+RG group compared to the HC diet group. However, this increase was not significant. Also, the difference between level of ROS in different groups was not statistically significant. Conclusion: Results of this study demonstrated that hydroalcoholic extract of RG significantly increases the activity of the Butyrylcholinesterase enzyme in the hippocampal tissue of treated rats compared to the HC group and also had a partial effect on the antioxidant levels and defense against Oxidative stress in the rats receiving HC diet but this difference was not statistically significant.

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APA: Copy

Bolouki, Elham, Naderi, Gholamali, ROGHANI, MEHRDAD, & ZAHEDI, ELHAM. (2019). The effect of hydroalcoholic extract of Ruta graveolens on oxidative stress markers and cholinesterase in brain rats receiving highcholesterol diet. DANESHVAR MEDICINE, 26(139 ), 41-50. SID. https://sid.ir/paper/30612/en

Vancouver: Copy

Bolouki Elham, Naderi Gholamali, ROGHANI MEHRDAD, ZAHEDI ELHAM. The effect of hydroalcoholic extract of Ruta graveolens on oxidative stress markers and cholinesterase in brain rats receiving highcholesterol diet. DANESHVAR MEDICINE[Internet]. 2019;26(139 ):41-50. Available from: https://sid.ir/paper/30612/en

IEEE: Copy

Elham Bolouki, Gholamali Naderi, MEHRDAD ROGHANI, and ELHAM ZAHEDI, “The effect of hydroalcoholic extract of Ruta graveolens on oxidative stress markers and cholinesterase in brain rats receiving highcholesterol diet,” DANESHVAR MEDICINE, vol. 26, no. 139 , pp. 41–50, 2019, [Online]. Available: https://sid.ir/paper/30612/en

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