THE EFFECT OF IMMUNOMODULATOR FRACTION OF GARLIC (R10) ON BLOOD PRESSURE, PROTEIN, CREATININE AND URIC ACID IN PREGNANT AND NON-PREGNANT MICE

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MOAIED MOHSENI SAKINE; MIRSHARIF ENSIEH SADAT; AIIOBI FATEMEH; EGHTEDARDOOST MARZIEH; EMADI MOHAMED REZA; HESHMATI MARJAN; GHAZANFARI TOOBA

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2011 | Volume:19 | Issue:95 Page(s): 17-26

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Title

THE EFFECT OF IMMUNOMODULATOR FRACTION OF GARLIC (R10) ON BLOOD PRESSURE, PROTEIN, CREATININE AND URIC ACID IN PREGNANT AND NON-PREGNANT MICE

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Keywords

IMMUNOMODULATOR FRACTION OF GARLIC (R10)Q2

BLOOD PRESSUREQ2

PROTEINQ2

CREATININEQ2

URIC ACIDQ2

PREECLAMPSIAQ2

PREGNANTQ2

Abstract

Background and Objective: Due to the effect of garlic on immune system and a relationship between immune responses and pregnancy outcome, we designed this study to evaluate the effect of immunomodulator fraction of garlic (R10) on main parameters in pregnancy period.Materials and Methods: One week after mating of 30 female BALB/c mice, they were divided into four groups: one group received R10 fraction for one week, one group received R10 fraction for two weeks and their corresponding control groups. Intraperitoneal injection of 0.2 mg/kg of the fraction continued until 18th days of pregnancy. During this time, BLOOD PRESSURE was measured and their urine for PROTEIN and creatinnine assay and serum for URIC ACID assay were collected.Results: Injection of 0.2 mg/kg of R10 fraction for two weeks significantly increased systolic BLOOD PRESSURE, declined urine PROTEIN and PROTEIN to craetinene ratio in non-pregnant mice. No significant difference was observed regarding urine CREATININE between the groups. In both groups (i.e. PREGNANT and non-pregnant) serum level of URIC ACID increased as compared to control group.Conclusion: Garlic isolated R10 fraction which was used at a higher dose in this study compared to its immunostimulatory dose increased BLOOD PRESSURE and URIC ACID. Since this may cause PREECLAMPSIA, it is suggested to have precaution for use of high dose garlic and R10 fraction in pregnancy period and more study are warranted on pregnancy in human and animal models.

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APA: Copy

MOAIED MOHSENI, SAKINE, MIRSHARIF, ENSIEH SADAT, AIIOBI, FATEMEH, EGHTEDARDOOST, MARZIEH, EMADI, MOHAMED REZA, HESHMATI, MARJAN, & GHAZANFARI, TOOBA. (2011). THE EFFECT OF IMMUNOMODULATOR FRACTION OF GARLIC (R10) ON BLOOD PRESSURE, PROTEIN, CREATININE AND URIC ACID IN PREGNANT AND NON-PREGNANT MICE. DANESHVAR MEDICINE, 19(95), 17-26. SID. https://sid.ir/paper/30623/en

Vancouver: Copy

MOAIED MOHSENI SAKINE, MIRSHARIF ENSIEH SADAT, AIIOBI FATEMEH, EGHTEDARDOOST MARZIEH, EMADI MOHAMED REZA, HESHMATI MARJAN, GHAZANFARI TOOBA. THE EFFECT OF IMMUNOMODULATOR FRACTION OF GARLIC (R10) ON BLOOD PRESSURE, PROTEIN, CREATININE AND URIC ACID IN PREGNANT AND NON-PREGNANT MICE. DANESHVAR MEDICINE[Internet]. 2011;19(95):17-26. Available from: https://sid.ir/paper/30623/en

IEEE: Copy

SAKINE MOAIED MOHSENI, ENSIEH SADAT MIRSHARIF, FATEMEH AIIOBI, MARZIEH EGHTEDARDOOST, MOHAMED REZA EMADI, MARJAN HESHMATI, and TOOBA GHAZANFARI, “THE EFFECT OF IMMUNOMODULATOR FRACTION OF GARLIC (R10) ON BLOOD PRESSURE, PROTEIN, CREATININE AND URIC ACID IN PREGNANT AND NON-PREGNANT MICE,” DANESHVAR MEDICINE, vol. 19, no. 95, pp. 17–26, 2011, [Online]. Available: https://sid.ir/paper/30623/en

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