NAFLD PREVALENCE IN A YOUNG CADAVERIC ORGAN DONOR POPULATION

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JAFARIAN ALI; EBRAHIMI AMIR PASHA; AZMOUDEH ARDALAN FARID; DASHTI HABIBOLLAH; RAHIMI MOJGAN; SALEHI MANDANA; NASIRI TOOSI MOHSEN

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Journal: Hepatitis Monthly Year:2014 | Volume:14 | Issue:10 Page(s): 0-0

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Title

NAFLD PREVALENCE IN A YOUNG CADAVERIC ORGAN DONOR POPULATION

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Keywords

STEATOSIS

NASH

NAFLD

PREVALENCE

CADAVER

Abstract

Background: Liver transplantation is a critical survival point for patients with end stage liver diseases. It can dramatically increase patients’ survival if the donor liver is intact. One aspect of liver health is absence of STEATOSIS. Nonalcoholic Steato Hepatitis (NASH) and Nonalcoholic Fatty Liver Disease (NAFLD) are increasing among young adults and patients living with chronic liver diseases.Objectives: In this study, we determined the PREVALENCE of NALFD in livers of brain-dead donors in Imam-Khomeini hospital Complex, Tehran, Iran. We assumed that the calculated PREVALENCE would represent NAFLD PREVALENCE in Iranian population in the age range of 20-60 years.Materials and Methods: All eligible brain dead liver transplant donors were enrolled in the survey from March 21, 2011 to March 21, 2013 in Imam-Khomeini hospital Complex. Eligible participants were donors aged 20 to 60 years without any obvious history of liver disease. Liver needle biopsy was performed at the end of the transplant operation, time zero biopsy. We calculated the PREVALENCE of NAFLD among brain-dead donors. Moreover, the frequency of NASH was calculated based on the NAS (NAFLD Activity Score).Results: Among 116 cases, two were diagnosed as probable NASH. There was a significant association between NAFLD and male gender (P=0.04). Moreover, we found a higher STEATOSIS level in male gender. There was a significant association between NAFLD and BMI (P=0.05). Those with BMI more than 27 had severe STEATOSIS.Conclusions: Our comprehensive literature review showed that our study was the first investigation in Iran and the region, which determined the PREVALENCE of NAFLD based on tissue diagnosis. We believe that the PREVALENCE of NAFLD/NASH in our donors can represent the overall PREVALENCE in this age group in Iran.

Cites

ASSOCIATION OF TUMOR NECROSIS FACTOR-ALPHA POLYMORPHISMS AND RISK OF CORONARY ARTERY DISEASE IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

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APA: Copy

JAFARIAN, ALI, EBRAHIMI, AMIR PASHA, AZMOUDEH ARDALAN, FARID, DASHTI, HABIBOLLAH, RAHIMI, MOJGAN, SALEHI, MANDANA, & NASIRI TOOSI, MOHSEN. (2014). NAFLD PREVALENCE IN A YOUNG CADAVERIC ORGAN DONOR POPULATION. HEPATITIS MONTHLY, 14(10), 0-0. SID. https://sid.ir/paper/306604/en

Vancouver: Copy

JAFARIAN ALI, EBRAHIMI AMIR PASHA, AZMOUDEH ARDALAN FARID, DASHTI HABIBOLLAH, RAHIMI MOJGAN, SALEHI MANDANA, NASIRI TOOSI MOHSEN. NAFLD PREVALENCE IN A YOUNG CADAVERIC ORGAN DONOR POPULATION. HEPATITIS MONTHLY[Internet]. 2014;14(10):0-0. Available from: https://sid.ir/paper/306604/en

IEEE: Copy

ALI JAFARIAN, AMIR PASHA EBRAHIMI, FARID AZMOUDEH ARDALAN, HABIBOLLAH DASHTI, MOJGAN RAHIMI, MANDANA SALEHI, and MOHSEN NASIRI TOOSI, “NAFLD PREVALENCE IN A YOUNG CADAVERIC ORGAN DONOR POPULATION,” HEPATITIS MONTHLY, vol. 14, no. 10, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/306604/en

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