POLYMORPHISMS WITHIN THE PROMOTER REGION OF THE GAMMA INTERFERON (IFN-γ) RECEPTOR1 GENE ARE ASSOCIATED WITH THE SUSCEPTIBILITY TO CHRONIC HBV INFECTION IN AN IRANIAN POPULATION

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KHANIZADE SAYAD; RAVANSHAD MEHRDAD; MOHEBBI SEYED REZA; NAGHOOSI HAMED; TAHAEI MOHAMAD ABRAHIM; MOUSAVI NASAB SEYED DAWOOD; ROMANI SARA; AZIMZADEH PEDRAM; SANATI AZAR; ZALI MOHAMMAD REZA

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Journal: Hepatitis Monthly Year:2012 | Volume:12 | Issue:11 Page(s): 0-0

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Title

POLYMORPHISMS WITHIN THE PROMOTER REGION OF THE GAMMA INTERFERON (IFN-γ) RECEPTOR1 GENE ARE ASSOCIATED WITH THE SUSCEPTIBILITY TO CHRONIC HBV INFECTION IN AN IRANIAN POPULATION

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Keywords

HEPATITIS B VIRUS

SINGLE NUCLEOTIDE POLYMORPHISM

INTERFERON GAMMA RECEPTOR

POLYMORPHISM

RESTRICTION FRAGMENT

LENGTH

Abstract

Background: chronic HEPATITIS B VIRUS (HBV) infection is a multifactorial disease that can result in serious clinical complications. Host genetic background especially the genes that encode immunologic factors like INF-g and its receptor (IFN-g R) are critical in the pathogenesis of infection.Objectives: The current study aimed to investigate the association between two POLYMORPHISM/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank"> SINGLE NUCLEOTIDE POLYMORPHISMs (SNPs) at positions -611 and -56 within the promoter region of gamma interferon receptor1 gene (IFN-g R1) and chronic HBV infection.Materials and Methods: Genomic DNA from peripheral blood samples of 200 chronically HBV infected patients and 200 healthy blood donors, as controls, were collected and genomic DNA was extracted by phenol-chloroform method and DNA analysis genotype identification was performed by PCR-RFLP.Results: The results indicated that both SNP’s frequency had a significant difference in the patient and control groups. At position -56, TT genotype was associated with patient group and P value was 0.002 and at position -611, GG genotype was further observed in control group and P value was 0.006.Conclusions: Presence of G allele at position -611 within promoter of IFN-g R1 gene in the enrolled population for the study was related to lower risk of disease, and presence of T allele at position -56 was also related to susceptibility to chronic HBV infection. Men had higher frequency of chronic HBV infection, which might be the result of high risk behavior.

Cites

ASSOCIATION BETWEEN IL-10 GENE PROMOTER POLYMORPHISMS (-592 A/C, -819 T/C, -1082 A/G) AND SUSCEPTIBILITY TO HBV INFECTION IN AN IRANIAN POPULATION

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APA: Copy

KHANIZADE, SAYAD, RAVANSHAD, MEHRDAD, MOHEBBI, SEYED REZA, NAGHOOSI, HAMED, TAHAEI, MOHAMAD ABRAHIM, MOUSAVI NASAB, SEYED DAWOOD, ROMANI, SARA, AZIMZADEH, PEDRAM, SANATI, AZAR, & ZALI, MOHAMMAD REZA. (2012). POLYMORPHISMS WITHIN THE PROMOTER REGION OF THE GAMMA INTERFERON (IFN-γ) RECEPTOR1 GENE ARE ASSOCIATED WITH THE SUSCEPTIBILITY TO CHRONIC HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY, 12(11), 0-0. SID. https://sid.ir/paper/306774/en

Vancouver: Copy

KHANIZADE SAYAD, RAVANSHAD MEHRDAD, MOHEBBI SEYED REZA, NAGHOOSI HAMED, TAHAEI MOHAMAD ABRAHIM, MOUSAVI NASAB SEYED DAWOOD, ROMANI SARA, AZIMZADEH PEDRAM, SANATI AZAR, ZALI MOHAMMAD REZA. POLYMORPHISMS WITHIN THE PROMOTER REGION OF THE GAMMA INTERFERON (IFN-γ) RECEPTOR1 GENE ARE ASSOCIATED WITH THE SUSCEPTIBILITY TO CHRONIC HBV INFECTION IN AN IRANIAN POPULATION. HEPATITIS MONTHLY[Internet]. 2012;12(11):0-0. Available from: https://sid.ir/paper/306774/en

IEEE: Copy

SAYAD KHANIZADE, MEHRDAD RAVANSHAD, SEYED REZA MOHEBBI, HAMED NAGHOOSI, MOHAMAD ABRAHIM TAHAEI, SEYED DAWOOD MOUSAVI NASAB, SARA ROMANI, PEDRAM AZIMZADEH, AZAR SANATI, and MOHAMMAD REZA ZALI, “POLYMORPHISMS WITHIN THE PROMOTER REGION OF THE GAMMA INTERFERON (IFN-γ) RECEPTOR1 GENE ARE ASSOCIATED WITH THE SUSCEPTIBILITY TO CHRONIC HBV INFECTION IN AN IRANIAN POPULATION,” HEPATITIS MONTHLY, vol. 12, no. 11, pp. 0–0, 2012, [Online]. Available: https://sid.ir/paper/306774/en

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