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Title

RELATIONSHIP BETWEEN HBV GENOTYPES B, C AND FOLLICULAR HELPER T CELLS IN PATIENTS WITH CHRONIC HEPATITIS B AND ITS SIGNIFICANCE

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Abstract

 Background: Clinical observations have shown that patients infected with chronic HEPATITIS B VIRUS (HBV) GENOTYPE C versus GENOTYPE B had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. However, the disparity between the two has not been clarified.Objectives: To explore possible relationship between HBV GENOTYPEs B and C and peripheral blood follicular helper T cells (Tfh) and its significance in treating chronic hepatitis B (CHB) patients.Patients and Methods: One hundred and fifty CHB patients were enrolled into this study, including 70 cases infected with HBV GENOTYPE C and 79 cases with GENOTYPE B. One patient had suffered from both GENOTYPEs B and C. The levels of Tfh, also known as INTERLEUKIN-21 (IL-21), HBV specific CYTOTOXIC T lymphocytes (CTL), HBV DNA and alanine transaminase (ALT) were evaluated and compared in patients infected with GENOTYPE B and C.Results: Levels of Tfh, IL-21 and HBV specific CTL of patients infected with HBV GENOTYPE C were significantly lower than those of patients infected with HBV GENOTYPE B, P<0.01. Levels of HBV DNA and ALT of patients infected with GENOTYPE C were significantly higher than those of the patients infected with HBV GENOTYPE B, P<0.01.Conclusions: Compared with chronic hepatitis B (CHB) patients infected with GENOTYPE B, higher levels of serum HBV DNA, ALT and TBil of patients infected with HBV GENOTYPE C may be related to their lower level of peripheral blood Tfh, which may result in lower IL-21, and it may result in lower HBV specific CTL.

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    APA: Copy

    XIBING, GU, XIAOJUAN, YANG, JUANHUA, WANG, & ZHONG, HUA. (2013). RELATIONSHIP BETWEEN HBV GENOTYPES B, C AND FOLLICULAR HELPER T CELLS IN PATIENTS WITH CHRONIC HEPATITIS B AND ITS SIGNIFICANCE. HEPATITIS MONTHLY, 13(1), 0-0. SID. https://sid.ir/paper/306860/en

    Vancouver: Copy

    XIBING GU, XIAOJUAN YANG, JUANHUA WANG, ZHONG HUA. RELATIONSHIP BETWEEN HBV GENOTYPES B, C AND FOLLICULAR HELPER T CELLS IN PATIENTS WITH CHRONIC HEPATITIS B AND ITS SIGNIFICANCE. HEPATITIS MONTHLY[Internet]. 2013;13(1):0-0. Available from: https://sid.ir/paper/306860/en

    IEEE: Copy

    GU XIBING, YANG XIAOJUAN, WANG JUANHUA, and HUA ZHONG, “RELATIONSHIP BETWEEN HBV GENOTYPES B, C AND FOLLICULAR HELPER T CELLS IN PATIENTS WITH CHRONIC HEPATITIS B AND ITS SIGNIFICANCE,” HEPATITIS MONTHLY, vol. 13, no. 1, pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/306860/en

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