EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY

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SANDOUGHDARAN SALEH; ALAVIAN SEYED MOAYED; SHARAFI HEIDAR; BEHNAVA BITA; SALIMI SHIMA; MEHRNOUSH LEILA; KARIMI ELIZEE PEGAH; KESHVARI MARYAM

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Journal: Hepatitis Monthly Year:2015 | Volume:15 | Issue:1 Page(s): 0-0

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Title

EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY

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Keywords

HEPATITIS C

PEGINTERFERON ALFA-2A

RIBAVIRIN

THALASSEMIA

Abstract

Background: Most thalassemic patients with chronic HEPATITIS C virus (HCV) infection do not respond to therapy with pegylated interferon (Peg-IFN) plus RIBAVIRIN (RBV) due to hepatic siderosis and RBV dose reduction caused by RBV-induced anemia.Objectives: In the present study, we recruited HCV genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with Peg-IFN plus RBV in order to evaluate the efficacy of a 72-week regimen of Peg-IFN plus RBV.Patients and Methods: In this retrospective study, 23 thalassemic patients with HCV genotype 1 infection who had prior relapse after treatment with Peg-IFN and RBV for 48 weeks were consecutively enrolled in this study for evaluation of the efficacy of a 72-week treatment regimen.Results: For the 21 included cases, mean age was 29.7 years; 81% were men and 28.6% had cirrhosis. At the end of the treatment, nine (42.9%) patients had an undetectable level of HCV RNA in their sera. However, six months after treatment completion four of these patients relapsed and a sustained virological response (SVR) was found in five (23.8%) patients. Undetectable HCV RNA level at week 4 (P=0.03) and undetectable HCV RNA level at week 12 (P<0.01) were found to be predictors of SVR. There was an average 47.9% increase in blood transfusion during therapy and treatment was discontinued for 12 (57.1%) patients prematurely.Conclusions: The present study suggests that thalassemic patients with chronic HEPATITIS C genotype 1 infection who did not achieve SVR after a course of therapy with Peg-IFN and RBV may benefit from being retreated with a 72-week regimen.

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APA: Copy

SANDOUGHDARAN, SALEH, ALAVIAN, SEYED MOAYED, SHARAFI, HEIDAR, BEHNAVA, BITA, SALIMI, SHIMA, MEHRNOUSH, LEILA, KARIMI ELIZEE, PEGAH, & KESHVARI, MARYAM. (2015). EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY. HEPATITIS MONTHLY, 15(1), 0-0. SID. https://sid.ir/paper/306883/en

Vancouver: Copy

SANDOUGHDARAN SALEH, ALAVIAN SEYED MOAYED, SHARAFI HEIDAR, BEHNAVA BITA, SALIMI SHIMA, MEHRNOUSH LEILA, KARIMI ELIZEE PEGAH, KESHVARI MARYAM. EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY. HEPATITIS MONTHLY[Internet]. 2015;15(1):0-0. Available from: https://sid.ir/paper/306883/en

IEEE: Copy

SALEH SANDOUGHDARAN, SEYED MOAYED ALAVIAN, HEIDAR SHARAFI, BITA BEHNAVA, SHIMA SALIMI, LEILA MEHRNOUSH, PEGAH KARIMI ELIZEE, and MARYAM KESHVARI, “EFFICACY OF PROLONGED TREATMENT WITH PEGYLATED INTERFERON (PEG-IFN) AND RIBAVIRIN IN THALASSEMIC PATIENTS WITH HEPATITIS C WHO RELAPSED AFTER PREVIOUS PEG-IFN-BASED THERAPY,” HEPATITIS MONTHLY, vol. 15, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306883/en

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