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Title

SERUM NX-DCP AS A NEW NONINVASIVE MODEL TO PREDICT SIGNIFICANT LIVER FIBROSIS IN CHRONIC HEPATITIS C

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Abstract

 Background: Finding a noninvasive method to predict LIVER FIBROSIS using inexpensive and easy-to-use markers is important.Objectives: We aimed to clarify whether NX-des- g-carboxyprothrombin (NX-DCP) could become a new noninvasive model to predict LIVER FIBROSIS in HEPATITIS C virus (HCV) related liver disease.Patients and Methods: We performed a prospective cohort study on a consecutive group of 101 patients who underwent liver BIOPSY for HCV-related liver disease at Kobe University Hospital. Laboratory measurements were performed on the same day as the BIOPSY. Factors associated with significant fibrosis (F3-4) were assessed by multivariate analyses. A comparison of predictive ability between multivariate factors and abovementioned noninvasive models was also performed.Results: Increase in serum NX-DCP was significantly related to increase in fibrosis stage (P=0.006). Moreover, NX-DCP was a multivariate factor associated with the presence of significant fibrosis F 3-4 (median 21 of F0-2 group vs. median 22 of F3-4 group with P = 0.002). The AUC of NX-DCP showed no significant differences compared with those of the AST-to-platelet ratio index (APRI), modified-APRI, the Göteborg University Cirrhosis Index (GUCI), the Lok index, the Hui score, cirrhosis discriminating score (CDS) and the Pohl score (P>0.05).Conclusions: NX-DCP correlated positively with fibrosis stage and could discriminate well between HCV-related patients with or without significant fibrosis. Moreover, NX-DCP had a similar predictive ability to the abovementioned models, and thereby could be a new noninvasive prediction tool for fibrosis.

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    APA: Copy

    SAITO, MASAYA, YANO, YOSHIHIKO, HIRANO, HIROTAKA, MOMOSE, KENJI, YOSHIDA, MASARU, & AZUMA, TAKESHI. (2015). SERUM NX-DCP AS A NEW NONINVASIVE MODEL TO PREDICT SIGNIFICANT LIVER FIBROSIS IN CHRONIC HEPATITIS C. HEPATITIS MONTHLY, 15(2), 0-0. SID. https://sid.ir/paper/306890/en

    Vancouver: Copy

    SAITO MASAYA, YANO YOSHIHIKO, HIRANO HIROTAKA, MOMOSE KENJI, YOSHIDA MASARU, AZUMA TAKESHI. SERUM NX-DCP AS A NEW NONINVASIVE MODEL TO PREDICT SIGNIFICANT LIVER FIBROSIS IN CHRONIC HEPATITIS C. HEPATITIS MONTHLY[Internet]. 2015;15(2):0-0. Available from: https://sid.ir/paper/306890/en

    IEEE: Copy

    MASAYA SAITO, YOSHIHIKO YANO, HIROTAKA HIRANO, KENJI MOMOSE, MASARU YOSHIDA, and TAKESHI AZUMA, “SERUM NX-DCP AS A NEW NONINVASIVE MODEL TO PREDICT SIGNIFICANT LIVER FIBROSIS IN CHRONIC HEPATITIS C,” HEPATITIS MONTHLY, vol. 15, no. 2, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/306890/en

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