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Title

CHARACTERIZATION OF OCCULT HEPATITIS B INFECTION AMONG INJECTING DRUG USERS IN TEHRAN, IRAN

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Abstract

 Background: HEPATITIS B virus (HBV) infection is a major health problem worldwide.Objectives: The aim of this study was to investigate the frequency of occult HEPATITIS B infection (OBI) and its associated risk factors, together with the molecular characterization of the virus in INJECTING DRUG USERs of Tehran.PatientsandMethods: The study consisted of 229 INJECTING DRUG USERs. Serumsamples were collectedandtested for the presence of HEPATITIS B core antibody (HBcAb) and HEPATITIS B surface antigen (HBsAg) by an enzyme-linked immunosorbent assay (ELISA). HBV B virus DNA was extracted from the serum samples, and a fragment of the S gene was amplified using the nested polymerase chain reaction. The GENOTYPE, subgenotypes, subtype, and S gene mutation of HBV were determined by direct sequencing. A phylogenetic tree was constructed using the neighbor-joining method.Results: Sixty-four (28%) participants were HBcAb positive, 59 cases were HBcAb positive and HBsAg negative, and 5 cases were HBsAg positive. HEPATITIS B DNA was found in three HBsAg-positive cases. Thirteen of 59 (22%) individuals were HEPATITIS B DNA positive.The phylogenetic tree of HEPATITIS B DNA showed the existence of GENOTYPE D. The only significant correlation was between sharing a syringe and OBI.Conclusions: In comparison with the rate of HBcAb positivity reported in other Iranian studies, the rate was higher in the present study. There were a few variations, GENOTYPEs, and subtypes among the infected INJECTING DRUG USERs. Further investigations are needed to unravel the molecular characterization of OBI.

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    APA: Copy

    ASLI, MARYAM, KANDELOUEI, TAHMINEH, RAHIMYAN, KOROUSH, DAVOODBEGLOU, FOAD, & VAEZJALALI, MARYAM. (2016). CHARACTERIZATION OF OCCULT HEPATITIS B INFECTION AMONG INJECTING DRUG USERS IN TEHRAN, IRAN. HEPATITIS MONTHLY, 16(3), 0-0. SID. https://sid.ir/paper/306983/en

    Vancouver: Copy

    ASLI MARYAM, KANDELOUEI TAHMINEH, RAHIMYAN KOROUSH, DAVOODBEGLOU FOAD, VAEZJALALI MARYAM. CHARACTERIZATION OF OCCULT HEPATITIS B INFECTION AMONG INJECTING DRUG USERS IN TEHRAN, IRAN. HEPATITIS MONTHLY[Internet]. 2016;16(3):0-0. Available from: https://sid.ir/paper/306983/en

    IEEE: Copy

    MARYAM ASLI, TAHMINEH KANDELOUEI, KOROUSH RAHIMYAN, FOAD DAVOODBEGLOU, and MARYAM VAEZJALALI, “CHARACTERIZATION OF OCCULT HEPATITIS B INFECTION AMONG INJECTING DRUG USERS IN TEHRAN, IRAN,” HEPATITIS MONTHLY, vol. 16, no. 3, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306983/en

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