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Title

LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION

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Abstract

 Background: Leptin receptor (LEPR) polymorphisms have been reported to be associated with lipid metabolism and insulin resistance in various populations. However, whether LEPR polymorphisms are associated with the risks of NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) and CORONARY ATHEROSCLEROSIS in the Chinese Han population remains unknown.Objectives: To investigate the association of LEPR polymorphisms at Q223R and K109R with the risks of NAFLD and CORONARY ATHEROSCLEROSIS in the Chinese Han population.Patients and Methods: Genotypes of LEPRQ223R and K109R were determined by polymerase chain reaction followed by sequencing in patients with NAFLD (n=554), CORONARY ATHEROSCLEROSIS (n=421), and healthy controls (n=550). Serum lipid profiles were determined using biochemical methods. Pearson’s c2 test was used to check for Hardy-Weinberg equilibrium and to analyze the distributions of genotypes’ alleles between groups. Baseline characteristics were analyzed using student’s t-test, paired-samples t-test, or the c2 test where appropriate.Results: The LEPRQ223R A allele significantly reduced the risks of both NAFLD and CORONARY ATHEROSCLEROSIS (OR=0.683, 95% CI: 0.527 - 0.884, P=0.004 andOR=0.724, 95% CI: 0.548 - 0.955, P=0.022, respectively). Compared to controls, no significant differences in the genotype and allele frequencies of K109R were found in the NAFLD and CORONARY ATHEROSCLEROSIS populations, respectively. However, there was a significantly increased risk of CORONARY ATHEROSCLEROSIS in NAFLD patients who carried the K109R A allele (OR=2.283, 95% CI: 1.556 - 3.348, P<0.001).Conclusions: LEPR Q223R polymorphisms may confer a significant risk of NAFLD and CORONARY ATHEROSCLEROSIS. The A allele in the K109R polymorphism might be considered an independent risk factor for CORONARY ATHEROSCLEROSIS in NAFLD patients.

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    APA: Copy

    AN, BAI QUAN, LU, LIN LIN, YUAN, CHEN, XIN, YONG NING, & XUAN, SHI YING. (2016). LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION. HEPATITIS MONTHLY, 16(4), 0-0. SID. https://sid.ir/paper/306997/en

    Vancouver: Copy

    AN BAI QUAN, LU LIN LIN, YUAN CHEN, XIN YONG NING, XUAN SHI YING. LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION. HEPATITIS MONTHLY[Internet]. 2016;16(4):0-0. Available from: https://sid.ir/paper/306997/en

    IEEE: Copy

    BAI QUAN AN, LIN LIN LU, CHEN YUAN, YONG NING XIN, and SHI YING XUAN, “LEPTIN RECEPTOR GENE POLYMORPHISMS AND THE RISK OF NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ATHEROSCLEROSIS IN THE CHINESE HAN POPULATION,” HEPATITIS MONTHLY, vol. 16, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/306997/en

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