THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT

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SHAYESTEH RAD FATEMEH; FARZANEGI PARVIN; HABIBIAN MASOUMEH; ALINEJAD HADI

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Journal: DANESHVAR MEDICINE Year:2017 | Volume:24 | Issue:129 Page(s): 65-74

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Title

THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT

Author(s)

SHAYESTEH RAD FATEMEH | FARZANEGI PARVIN | HABIBIAN MASOUMEH | ALINEJAD HADI | Issue Writer Certificate

Keywords

AEROBIC TRAININGQ1

GARLIC EXTRACTQ2

APOPTOSISQ2

DOXORUBICINQ1

Abstract

Background and Objective: Increased oxidative damage to DNA can be mentioned as the main cause of age-related diseases. This damage can result in translation of specific genes which regulate cell proliferation and APOPTOSIS. The aim of this study was to investigate the effect of a regular swimming training with GARLIC EXTRACT on the levels of Bax and Bcl-2 in the liver tissue DOXORUBICIN -induced aging rat Materials and Methods: In this study, 42 aged male rats, 40-50 weeks, with an average initial weight of 250-300g were randomly divided into 6 groups: 1.control, 2. saline, 3. DOXORUBICIN, 4. DOXORUBICIN+exercise, 5. DOXORUBICIN+garlic, and 6. DOXORUBICIN+garlic+exercise. Chronic kidney disease (CKD) was induced by injection of 8.5 ml/kg of DOXORUBICIN. The animals in the exercise groups were forced to swim 30 min once a day, 3 days per week, for 8 weeks. Groups receiving supplement and exercise+supplement, daily treated with 1ml of GARLIC EXTRACT per kilogram of body weight for 8 weeks orally (gavage). In addition, 48 hours after the last training session and after 12-10 hours of fasting, rats were anesthetized and liver tissue separated immediately and stored at -70ᵒ C to measure the levels of Bax and Bcl-2. For comparisons among the groups, oneway analysis of variance (ANOVA) and Tukey’s test were performed with P<0.05 as an indication of statistical significance.Results: The findings showed that eight weeks of swimming training and GARLIC EXTRACT and the combination of exercise training and GARLIC EXTRACT resulted in a significant increase in the levels of Bcl-2 and also a significant decrease in the levels of Bax and Bax/Bcl-2 in the kidney tissue of aged rats induced by DOXORUBICIN (P<0.05).Conclusion: Exercise training, herbal supplement of garlic, and a combination of these two methods can be as an effective non-pharmacological therapy to reduce liver damage and protect liver tissue against oxidative stress and inflammatory injuries associated with aging.

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References

EFFECT OF DOXORUBICIN ON BCL2 AND BAX EXPRESSION IN RAT HEART

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APA: Copy

SHAYESTEH RAD, FATEMEH, FARZANEGI, PARVIN, HABIBIAN, MASOUMEH, & ALINEJAD, HADI. (2017). THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT. DANESHVAR MEDICINE, 24(129), 65-74. SID. https://sid.ir/paper/30754/en

Vancouver: Copy

SHAYESTEH RAD FATEMEH, FARZANEGI PARVIN, HABIBIAN MASOUMEH, ALINEJAD HADI. THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT. DANESHVAR MEDICINE[Internet]. 2017;24(129):65-74. Available from: https://sid.ir/paper/30754/en

IEEE: Copy

FATEMEH SHAYESTEH RAD, PARVIN FARZANEGI, MASOUMEH HABIBIAN, and HADI ALINEJAD, “THE EFFECT OF REGULAR SWIMMING TRAINING AND GARLIC EXTRACT ON APOPTOSIS OF LIVER CELLS IN DOXORUBICIN-INDUCED AGING RAT,” DANESHVAR MEDICINE, vol. 24, no. 129, pp. 65–74, 2017, [Online]. Available: https://sid.ir/paper/30754/en

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