EFFECT OF PRETREATMENT OF AEROBIC TRAINING ON DOXORUBICININDUCED LEFT VENTRICULAR APOPTOSIS GENE EXPRESSION IN AGING RAT MODEL

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SHARIFI FATEMEH; DABIDI ROSHAN VALIOLLAH; MAZAHERI ZOHREH

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Journal: Pathobiology Research Year:2016 | Volume:19 | Issue:2 Page(s): 29-43

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Title

EFFECT OF PRETREATMENT OF AEROBIC TRAINING ON DOXORUBICININDUCED LEFT VENTRICULAR APOPTOSIS GENE EXPRESSION IN AGING RAT MODEL

Author(s)

SHARIFI FATEMEH | DABIDI ROSHAN VALIOLLAH | MAZAHERI ZOHREH | Issue Writer Certificate

Keywords

DOXORUBICINQ2

CARDIOTOXICITYQ1

PRE-TREATMENTQ2

AEROBIC EXERCISEQ2

HEART APOPTOSISQ1

Abstract

Objective: Aging can affect adaption of the heart tissue’s apoptotic system to AEROBIC EXERCISE and induction of DOXORUBICIN. Therefore, this study aims to evaluate the effect of pretreatment of aerobic training on DOXORUBICIN-induced left ventricular apoptosis gene expression in a model of aging rats.Methods: We randomly assigned 42 adult Wistar male rats to 6 groups (n=7 per group): control of young, control of aging, aging+saline, aging+DOXORUBICIN, aging+aerobic exercise+saline, and aging+aerobic exercise+DOXORUBICIN. Aging was induced by an intraperitoneal (i.p.) injection of D- galactose (100 mg/kg). The training protocol included treadmill running with a gradual increase from 25 min/day to 54 min/day at a velocity of 15 m/min to 20 m/min, 5 days/week for 6 weeks. During the two ultimate training weeks, the animals underwent a 15-day i.p. DOXORUBICIN regimen that consisted of 1 mg/kg of DOXORUBICIN per day. The rats were sacrificed 48 hours after the last training and injection session. A portion of the left ventricle was analyzed by real-time PCR for Bax and Bcl-2 gene expressions.Results: ANOVA indicated that DOXORUBICIN injection induced a significant increase in expression of Bax and Bax/Bcl-2 ratio and an insignificant decrease in Bcl-2 gene expression. On the other hand, aerobic training before and during the induction of DOXORUBICIN prevented an increase in the Bax/Bcl-2 ratio and the DOXORUBICIN-induced decrease inBcl-2 gene expression.Conclusion: Due to the significant decrease in Bax/Bcl-2 ratio in the hearts of the trained rats that underwent DOXORUBICIN treatment, we conclude that AEROBIC EXERCISE training prior to and during treatment with DOXORUBICIN as a non-pharmacological strategy, probably protects cardiomyocytes from DOXORUBICIN-induced apoptosis.

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APA: Copy

SHARIFI, FATEMEH, DABIDI ROSHAN, VALIOLLAH, & MAZAHERI, ZOHREH. (2016). EFFECT OF PRETREATMENT OF AEROBIC TRAINING ON DOXORUBICININDUCED LEFT VENTRICULAR APOPTOSIS GENE EXPRESSION IN AGING RAT MODEL. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 19(2), 29-43. SID. https://sid.ir/paper/81034/en

Vancouver: Copy

SHARIFI FATEMEH, DABIDI ROSHAN VALIOLLAH, MAZAHERI ZOHREH. EFFECT OF PRETREATMENT OF AEROBIC TRAINING ON DOXORUBICININDUCED LEFT VENTRICULAR APOPTOSIS GENE EXPRESSION IN AGING RAT MODEL. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2016;19(2):29-43. Available from: https://sid.ir/paper/81034/en

IEEE: Copy

FATEMEH SHARIFI, VALIOLLAH DABIDI ROSHAN, and ZOHREH MAZAHERI, “EFFECT OF PRETREATMENT OF AEROBIC TRAINING ON DOXORUBICININDUCED LEFT VENTRICULAR APOPTOSIS GENE EXPRESSION IN AGING RAT MODEL,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 19, no. 2, pp. 29–43, 2016, [Online]. Available: https://sid.ir/paper/81034/en

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