TISSUE TOXICITY INDUCED BY DOXORUBICIN IN RATS: PROTECTIVE ROLE OF AEROBIC REGULAR EXERCISE

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ASHRAFI HELAN JAVAD; DABIDI ROSHAN VALIOLLAH; ZOLFAGHARZADEH FATEMEH

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Journal: Studies in Medical Sciences Year:2014 | Volume:25 | Issue:4 Page(s): 353-362

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Title

TISSUE TOXICITY INDUCED BY DOXORUBICIN IN RATS: PROTECTIVE ROLE OF AEROBIC REGULAR EXERCISE

Author(s)

ASHRAFI HELAN JAVAD | DABIDI ROSHAN VALIOLLAH | ZOLFAGHARZADEH FATEMEH | Issue Writer Certificate

Keywords

CANCERQ2

DOXORUBICINQ2

AEROBIC TRAININGQ2

OXIDATIVE STRESSQ2

Abstract

Background & Aims: DOXORUBICIN (DOX) is an anthracycline antibiotic that is widely used as an antiCANCER agent. However, the clinical use of DOX is limited due to its toxic side effects upon nontarget tissues. The aim of this study was to investigate the impact of 6 weeks of AEROBIC TRAINING on dox-induced toxicity in rat tissues (heart and liver).Materials & Methods: This study was conducted on thirty-two Wistar male rats randomly assigned to 1.control+salin, 2. control+DOX, 3. training+salin, 4) training+DOX groups. Groups 3 and 4 were trained on treadmill between 25 to 54 min/day and 15 to 20 m/min, 5 days/week for 6 weeks. The groups 2, 4 and groups 1, 3 received DOX (20 mg.kg-1 i.p) and saline (0.9% NaCl i.p), respectively.Animals were sacrificed 24 h after DOX and saline injections. Also, heart and liver tissue homogenization and assay parameters were performed.Results: DOXORUBICIN administration cause a significant increase in malondialdehyde (MDA), nitric oxide (NO) and a significant decrease in the superoxide dismutase (SOD) activity in heart and liver tissues; however, the difference was not significant between the two tissues. Although the 6-week AEROBIC TRAINING+DOX caused a down-regulation of oxidant markers and up-regulation of the SOD activity in heart and liver tissues, but only changes of the SOD activity was significant between the heart and liver tissues.Conclusion: Our study suggests that cardiac/liver protection induced by chronically exercise in DOX treated rats is associated with inhibition of OXIDATIVE STRESS and increase in the antioxidant defense levels.

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APA: Copy

ASHRAFI HELAN, JAVAD, DABIDI ROSHAN, VALIOLLAH, & ZOLFAGHARZADEH, FATEMEH. (2014). TISSUE TOXICITY INDUCED BY DOXORUBICIN IN RATS: PROTECTIVE ROLE OF AEROBIC REGULAR EXERCISE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 25(4), 353-362. SID. https://sid.ir/paper/403997/en

Vancouver: Copy

ASHRAFI HELAN JAVAD, DABIDI ROSHAN VALIOLLAH, ZOLFAGHARZADEH FATEMEH. TISSUE TOXICITY INDUCED BY DOXORUBICIN IN RATS: PROTECTIVE ROLE OF AEROBIC REGULAR EXERCISE. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2014;25(4):353-362. Available from: https://sid.ir/paper/403997/en

IEEE: Copy

JAVAD ASHRAFI HELAN, VALIOLLAH DABIDI ROSHAN, and FATEMEH ZOLFAGHARZADEH, “TISSUE TOXICITY INDUCED BY DOXORUBICIN IN RATS: PROTECTIVE ROLE OF AEROBIC REGULAR EXERCISE,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 25, no. 4, pp. 353–362, 2014, [Online]. Available: https://sid.ir/paper/403997/en

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