TREATMENT OF RAT MODEL EPILEPSY WITH BONE MARROW STROMAL CELLS AND EVALUATE OF DIFFERENTIATION INJECTED CELLS TO MATURE NEURONS

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ABDANIPOUR A.R.; ALTARIHI T.; MIRNAJAFIZADEH S.J.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2008 | Volume:15 | Issue:75 Page(s): 37-50

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Title

TREATMENT OF RAT MODEL EPILEPSY WITH BONE MARROW STROMAL CELLS AND EVALUATE OF DIFFERENTIATION INJECTED CELLS TO MATURE NEURONS

Author(s)

ABDANIPOUR A.R. | ALTARIHI T. | MIRNAJAFIZADEH S.J. | Issue Writer Certificate

Keywords

BMSCS (BONE MARROW STROMAL CELLS)Q3

EPILEPSYQ3

PILOCARPINEQ2

INTRAVENOUS INJECTIONQ3

Abstract

Introduction: Treatment of EPILEPSY with Bone Marrow Stromal Cells and evaluate of differentiation injected cells to mature neurons.Materials & Methods: The rats were divided into five groups, controls (untreated), tow treated groups (24 and 36 hours) and a group treated with the vehicle only. The animals in chronic phase were monitored via video monitoring system for three weeks (day & night). For assessment of the response for the treatment of epileptic’s rat using BMSCs therapy, Racine scale was used as a behavioral test (Turski 1972). BMSCs (2-3 million cells) were labeled with BrdU and were injected via tail vein rat 24, 36 hrs after first seizure. After 6 week all rats sacrificed and processed for paraffin, sectioned and for Cresol violet staining.Results: The result of the study showed that the behavioral test in three week as follows: in control group (untreated), number of seizure is 6.25±1.3; in vehicle group, number of seizure was 6.2±0.8; the group which received BMSCs 12 h after seizure all rats died; the group which received BMSCs (24 h after seizure), the number was 2±0.4 and the group which received BMSCs (36 h after seizure), the number of seizure was 2.25±0.47. The numerical density of cells per area (#/mm2) was showed that number of cells in 36h & 24h groups compared with control group significantly excessive. Hence injection of BMSCs can improve number of attacks in epileptic’s rats. The percent of migrated BMSCs in hippocampus region was 15.8% for 24 h group and 13.2% for 34 h group which detected by anti-BrdU antibody.Conclusion: Injection of bone marrow stromal cells can reduce the number of attacks in rat model EPILEPSY.

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APA: Copy

ABDANIPOUR, A.R., ALTARIHI, T., & MIRNAJAFIZADEH, S.J.. (2008). TREATMENT OF RAT MODEL EPILEPSY WITH BONE MARROW STROMAL CELLS AND EVALUATE OF DIFFERENTIATION INJECTED CELLS TO MATURE NEURONS. DANESHVAR MEDICINE, 15(75), 37-50. SID. https://sid.ir/paper/30861/en

Vancouver: Copy

ABDANIPOUR A.R., ALTARIHI T., MIRNAJAFIZADEH S.J.. TREATMENT OF RAT MODEL EPILEPSY WITH BONE MARROW STROMAL CELLS AND EVALUATE OF DIFFERENTIATION INJECTED CELLS TO MATURE NEURONS. DANESHVAR MEDICINE[Internet]. 2008;15(75):37-50. Available from: https://sid.ir/paper/30861/en

IEEE: Copy

A.R. ABDANIPOUR, T. ALTARIHI, and S.J. MIRNAJAFIZADEH, “TREATMENT OF RAT MODEL EPILEPSY WITH BONE MARROW STROMAL CELLS AND EVALUATE OF DIFFERENTIATION INJECTED CELLS TO MATURE NEURONS,” DANESHVAR MEDICINE, vol. 15, no. 75, pp. 37–50, 2008, [Online]. Available: https://sid.ir/paper/30861/en

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