CD86+1057G>A POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE KIDNEY ALLOGRAFT REJECTION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KRICHEN HENDA; SFAR IMEN; BARDI RAFIKA; BEN ABDALLAH TAIEB; JENDOUBI AYED SALWA; BEN ALEYA WALID; MAKHLOUF MOUNA; BEN RHOMDHANE THOURAYA; AOUADI HOUDA; ABDERRAHIM EZZEDDINE; AYED KHALED; GORGI YOUSR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Kidney Diseases Year:2011 | Volume:5 | Issue:3 Page(s): 187-193

Download Full-Text

View:

367

Download:

147

Cites:

Information Journal Paper

Title

CD86+1057G>A POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE KIDNEY ALLOGRAFT REJECTION

Author(s)

Keywords

GRAFT REJECTION

CD86 PROTEIN

GENETIC POLYMORPHISM

KIDNEY TRANSPLANTATION

Abstract

Introduction. CD86 is a costimulatory molecule that participates in the regulation of T-cell lymphocytes activation. Thus, we examined a genetic marker on theCD86 gene in kidney transplant outcome.Materials and Methods. In our retrospective study, 168 kidney allograft recipients were genotyped by direct sequencing. Patients were classified into 2 groups of 29 human leukocyte antigen (HLA)-identical haplotype allograft recipients and 139 recipients showing one or more mismatches in the HLA haplotype. Forty-five patients (26.8%) developed at least 1 acute rejection (AR) episode, 7 in the first and 38 in the second group.Results. Acute rejection was associated with the presence anti-HLA antibodies before transplantation (P=.03). The AA genotype and A allele at position+1057 in theCD86 gene were more frequent in patients without AR (9.75% and 28.5%, respectively) compared with those showing an AR (2.22% and 23.3%, respectively). This difference was statistically significant in the anti-HLA-positive recipients, as AA frequency was 31.3% in non-AR patients and zero in AR ones (P=.04) and A allele frequency was 46.9% and 20.8%, respectively (P=.04). Patients bearing AA genotype reached a higher graft survival time (9.84 years) than those carrying GA (8.21 years, P=.32) or GG (7.61 years, P=.72) genotypes.Conclusion. These results suggest that AA genotype and A allele ofCD86+1057G>A polymorphism may confer a protection against acute kidney alloGRAFT REJECTION in Tunisian patients.

Cites

No record.

References

No record.

Cite

APA: Copy

KRICHEN, HENDA, SFAR, IMEN, BARDI, RAFIKA, BEN ABDALLAH, TAIEB, JENDOUBI AYED, SALWA, BEN ALEYA, WALID, MAKHLOUF, MOUNA, BEN RHOMDHANE, THOURAYA, AOUADI, HOUDA, ABDERRAHIM, EZZEDDINE, AYED, KHALED, & GORGI, YOUSR. (2011). CD86+1057G>A POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE KIDNEY ALLOGRAFT REJECTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(3), 187-193. SID. https://sid.ir/paper/309172/en

Vancouver: Copy

KRICHEN HENDA, SFAR IMEN, BARDI RAFIKA, BEN ABDALLAH TAIEB, JENDOUBI AYED SALWA, BEN ALEYA WALID, MAKHLOUF MOUNA, BEN RHOMDHANE THOURAYA, AOUADI HOUDA, ABDERRAHIM EZZEDDINE, AYED KHALED, GORGI YOUSR. CD86+1057G>A POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE KIDNEY ALLOGRAFT REJECTION. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(3):187-193. Available from: https://sid.ir/paper/309172/en

IEEE: Copy

HENDA KRICHEN, IMEN SFAR, RAFIKA BARDI, TAIEB BEN ABDALLAH, SALWA JENDOUBI AYED, WALID BEN ALEYA, MOUNA MAKHLOUF, THOURAYA BEN RHOMDHANE, HOUDA AOUADI, EZZEDDINE ABDERRAHIM, KHALED AYED, and YOUSR GORGI, “CD86+1057G>A POLYMORPHISM AND SUSCEPTIBILITY TO ACUTE KIDNEY ALLOGRAFT REJECTION,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 3, pp. 187–193, 2011, [Online]. Available: https://sid.ir/paper/309172/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops