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Information Journal Paper

Title

IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN EXPRESSION AS A PROGNOSTIC FACTOR IN WILMS TUMOR

Pages

  149-153

Abstract

 Introduction. Histological typing, especially the evidence of anaplasia and stage of the tumor are two major prognostic indicators in WILMS TUMOR, but some genetic factors have recently been noted. Mutations inTP53, which is a tumor suppressor gene, have been demonstrated to be associated with poor PROGNOSIS in some malignancies. There are also few studies which have confirmed the correlation between p53 protein overexpression and advanced course in WILMS TUMOR. This study was conducted to determine the correlation p53 immunoexpression and PROGNOSIS and outcome of WILMS TUMOR.Materials and Methods. The overexpression of p53 in 44 specimens of children (26 boys and 18 girls) with WILMS TUMOR (median age, 36 months; range, 4 to 96 months) was assessed in Mofid Children’s Hospital, Tehran, Iran. The overexpression of p53 was determined by immunohistochemistry with antihuman p53 antibody.Results. A positive immunostaining for p53 was detected in 24 of the 44 cases (54.7%). The grade of the tumor and anaplasia were associated with p53 positivity, but there was no association of p53 with the tumor stage. In comparison to p53 negatives, week-moderate and high p53-expressing tumors had significantly decreased the overall survival (hazard ratio, 3.75 and 8.61; P=.05 andP=.01, respectively).Conclusions. Overexpression of p53 protein in WILMS TUMOR is an indicator of poor pro gnosis, because it is correlated with unfavorable histology tumors and a shorter survival period.

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    APA: Copy

    JADALI, FARZANEH, SAYADPOUR, DELARAM, RAKHSHAN, MOHAMMAD, KARIMI, ABDOLLAH, ROUZROKH, MOHSEN, SHAMSIAN, BIBI SHAHIN, & SHAMSHIRI, AHMAD REZA. (2011). IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN EXPRESSION AS A PROGNOSTIC FACTOR IN WILMS TUMOR. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), 5(3), 149-153. SID. https://sid.ir/paper/309173/en

    Vancouver: Copy

    JADALI FARZANEH, SAYADPOUR DELARAM, RAKHSHAN MOHAMMAD, KARIMI ABDOLLAH, ROUZROKH MOHSEN, SHAMSIAN BIBI SHAHIN, SHAMSHIRI AHMAD REZA. IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN EXPRESSION AS A PROGNOSTIC FACTOR IN WILMS TUMOR. IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD)[Internet]. 2011;5(3):149-153. Available from: https://sid.ir/paper/309173/en

    IEEE: Copy

    FARZANEH JADALI, DELARAM SAYADPOUR, MOHAMMAD RAKHSHAN, ABDOLLAH KARIMI, MOHSEN ROUZROKH, BIBI SHAHIN SHAMSIAN, and AHMAD REZA SHAMSHIRI, “IMMUNOHISTOCHEMICAL DETECTION OF P53 PROTEIN EXPRESSION AS A PROGNOSTIC FACTOR IN WILMS TUMOR,” IRANIAN JOURNAL OF KIDNEY DISEASES (IJKD), vol. 5, no. 3, pp. 149–153, 2011, [Online]. Available: https://sid.ir/paper/309173/en

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