THE COMPARISON LYMPHOCYTE SUB- POPULATIONS TO LYMPHOCYTE ACTIVATION MARKERS IN PULMONARY TB PATIENTS

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ZAHMATKESH M.; AZIMI GH.; MIRSAEIDI SEYED MAHDI

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2007 | Volume:14 | Issue:70 Page(s): 33-40

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Title

THE COMPARISON LYMPHOCYTE SUB- POPULATIONS TO LYMPHOCYTE ACTIVATION MARKERS IN PULMONARY TB PATIENTS

Author(s)

ZAHMATKESH M. | AZIMI GH. | MIRSAEIDI SEYED MAHDI | Issue Writer Certificate

Keywords

TUBERCULOSIS (TB)Q3

LYMPHOCYTEQ3

MARKERQ3

LYMPHOCYTE ACTIVATION MARKERQ3

Abstract

Introduction: Tuberculosis is still a major health problem around the world Should we get better knowledge of different aspects of the disease, including immunology and immuno-pathogenesis, we can take better control measures. Studies regarding the quantitative and qualitative changes of LYMPHOCYTEs have increased our knowledge to a great extent. In these study quantitative deficiencies of LYMPHOCYTE sub-populations and their activation MARKERs have been investigated.Materials & Methods: Following documentation of smear positive pulmonary Tuberculosis in adult patients referred to Massih Daneshvari Hospital, 40 new cases without any other immunodeficiency conditions such as HIV, CRF, etc. were randomly selected. Tuberculin skin test (TST) and chest radiography were performed for each case, and flow-cytometry was done from peripheral blood for LYMPHOCYTE sub-populations as CD3, CD4, CD4/CD8 ratio, CD19, CD16+56, and for LYMPHOCYTE activation MARKERs including CD25, CD69 and HLA-DR. Comparisons were made for the historical control group with same age flow-cytometry operator and including & excluding criteria. Statistical analysis was done using Spearman's rho, Mann-Whitney U, and Asymp Sig (in a study in the same city, 2-tailed). Results: 18 cases (45%) were male and 22 (55%) were female. Age distribution had a minimum of 17 and a maximum of 80 with a mean of 44.18 (19.65). Considering flow-cytometric MARKER correlations, HLA-DR had significant relation with age (p=0.002). The ratio of CD4+ cells also had significant relation with CD3, CD16+56 and HLA-DR MARKERs. A significant difference was found only in the total of CD3+ LYMPHOCYTEs by comparing PPD positive cases (>or =10mm) to PPD negative patients. The ratio of CD4+cells also was significantly lower than the normal population; however, CD8+ was significantly higher compared to the control population. The CD4/CD8 ratio was also significantly lower than the normal population. Conclusion: The expression of LYMPHOCYTE sub-populations during the course of pulmonary Tuberculosis disease showed positive or to negative correlation. By comparing LYMPHOCYTE sub-populations of TB patients the control group, it can be concluded that CD4+, CD8+, and CD4/CD ratio show significant differences that confirm significant quantitative defects in LYMPHOCYTEs due to tuberculosis disease.

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APA: Copy

ZAHMATKESH, M., AZIMI, GH., & MIRSAEIDI, SEYED MAHDI. (2007). THE COMPARISON LYMPHOCYTE SUB- POPULATIONS TO LYMPHOCYTE ACTIVATION MARKERS IN PULMONARY TB PATIENTS. DANESHVAR MEDICINE, 14(70), 33-40. SID. https://sid.ir/paper/30997/en

Vancouver: Copy

ZAHMATKESH M., AZIMI GH., MIRSAEIDI SEYED MAHDI. THE COMPARISON LYMPHOCYTE SUB- POPULATIONS TO LYMPHOCYTE ACTIVATION MARKERS IN PULMONARY TB PATIENTS. DANESHVAR MEDICINE[Internet]. 2007;14(70):33-40. Available from: https://sid.ir/paper/30997/en

IEEE: Copy

M. ZAHMATKESH, GH. AZIMI, and SEYED MAHDI MIRSAEIDI, “THE COMPARISON LYMPHOCYTE SUB- POPULATIONS TO LYMPHOCYTE ACTIVATION MARKERS IN PULMONARY TB PATIENTS,” DANESHVAR MEDICINE, vol. 14, no. 70, pp. 33–40, 2007, [Online]. Available: https://sid.ir/paper/30997/en

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