INTENSIFIED CONVULSIONS INDUCED THROUGH INTRAVENOUS INFUSION OF PTZ BY NEPETA MENTHOIDES HYDROALCOHOLIC EXTRACT IN MICE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEYDARI AZHDAR; RAHMATI BATOOL; KHALILI MOHSEN; ROGHANI MEHRDAD; ZAERI FATEMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2015 | Volume:22 | Issue:119 Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,298

Download:

Cites:

Information Journal Paper

Title

INTENSIFIED CONVULSIONS INDUCED THROUGH INTRAVENOUS INFUSION OF PTZ BY NEPETA MENTHOIDES HYDROALCOHOLIC EXTRACT IN MICE

Author(s)

Keywords

NEPETA MENTHOIDESQ2

USTUKHUDDOOSQ2

PENTYLENETETRAZOLE INFUSIONQ2

CONVULSIONQ3

SEIZUREQ2

Abstract

Background and Objective: Repeated application of USTUKHUDDOOS has been recommended for a long time in Iranian traditional medicine for some of nervous disorders like epilepsy. In Iran, both imported Lavandula officinalis and endemic NEPETA MENTHOIDES are commonly known as USTUKHUDDOOS. Despite of some reports about antiepileptic and antioxidant effects of Lavandula officinalis, there is no available report for this effect of NEPETA MENTHOIDES. Therefore, this study was designed to investigate the anti-epileptic and antioxidant activity of NEPETA MENTHOIDES extract on timed intravenous pentylenetetrazol infusion SEIZURE in mice model.Materials and Methods: A convulsive model that utilizes timed intravenous infusions of pentylenetetrazol (PTZ) was developed to study anticonvulsant and antioxidant effect of ten days NEPETA MENTHOIDES pretreatment in mice. PTZ was infused through an indwelling tail vein catheter, and the threshold dose of PTZ was determined from the time needed to produce clonic CONVULSIONs, the body weight of the animal, and the rate of infusion of PTZ. Diazepam (Diaz), a major antiepileptic drug, was also tested for comparison.Results: Versus diazepam, NEPETA MENTHOIDES did not show antiepileptic properties because of not only it did not increase threshold dose of PTZ but also significantly decreased it at some doses (p<0.05). It means NEPETA MENTHOIDES significantly increased susceptibility to SEIZUREs. NEPETA MENTHOIDES also significantly increased brain nitric oxide (NO) level in comparison with control group (p<0.05) and it was ineffective on MDA level.Conclusion: This study reported that NEPETA MENTHOIDES not only did not prevent SEIZUREs, but also increased susceptibility to SEIZUREs. Also, due to an increase in NO by Nepeta, nitric oxide may be a progenitor agent for epilepsy.

Cites

No record.

References

No record.

Cite

APA: Copy

HEYDARI, AZHDAR, RAHMATI, BATOOL, KHALILI, MOHSEN, ROGHANI, MEHRDAD, & ZAERI, FATEMEH. (2015). INTENSIFIED CONVULSIONS INDUCED THROUGH INTRAVENOUS INFUSION OF PTZ BY NEPETA MENTHOIDES HYDROALCOHOLIC EXTRACT IN MICE. DANESHVAR MEDICINE, 22(119), 0-0. SID. https://sid.ir/paper/31007/en

Vancouver: Copy

HEYDARI AZHDAR, RAHMATI BATOOL, KHALILI MOHSEN, ROGHANI MEHRDAD, ZAERI FATEMEH. INTENSIFIED CONVULSIONS INDUCED THROUGH INTRAVENOUS INFUSION OF PTZ BY NEPETA MENTHOIDES HYDROALCOHOLIC EXTRACT IN MICE. DANESHVAR MEDICINE[Internet]. 2015;22(119):0-0. Available from: https://sid.ir/paper/31007/en

IEEE: Copy

AZHDAR HEYDARI, BATOOL RAHMATI, MOHSEN KHALILI, MEHRDAD ROGHANI, and FATEMEH ZAERI, “INTENSIFIED CONVULSIONS INDUCED THROUGH INTRAVENOUS INFUSION OF PTZ BY NEPETA MENTHOIDES HYDROALCOHOLIC EXTRACT IN MICE,” DANESHVAR MEDICINE, vol. 22, no. 119, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/31007/en

Related Journal Papers