EFFECTS OF TREATMENT WITH PLATINUM AZIDOTHYMIDINE AND AZIDOTHYMIDINE ON TELOMERASE ACTIVITY AND BCL-2 CONCENTRATION IN HEPATOCELLULAR CARCINOMA- INDUCED RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SABOKROUH ABDOLREZA; GOODARZI MOHAMAD TAGHI; VAISI RAYGANI ASAD; KHATAMI SHOHREH; TAGHIZADEH JAHED MASOUD

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Avicenna Journal of Medical Biotechnology Year:2014 | Volume:6 | Issue:4 Page(s): 200-209

Download Full-Text

View:

540

Download:

146

Cites:

Information Journal Paper

Title

EFFECTS OF TREATMENT WITH PLATINUM AZIDOTHYMIDINE AND AZIDOTHYMIDINE ON TELOMERASE ACTIVITY AND BCL-2 CONCENTRATION IN HEPATOCELLULAR CARCINOMA- INDUCED RATS

Author(s)

Keywords

HEPATOCELLULAR CARCINOMA

PLATINUM AZIDOTHYMIDINE

TELOMERASE ACTIVITY

Abstract

Background: TELOMERASE ACTIVITY increases in cancer cells. Bcl-2 is an antiapoptotic factor that its concentration grows in many cancer cells including HEPATOCELLULAR CARCINOMA cells. In this study, an attempt was made to investigate the effects of a new synthetic compound, PLATINUM AZIDOTHYMIDINE (Pt-AZT) on treatment of rats with HEPATOCELLULAR CARCINOMA (HCC) and to compare its effects with azidothymidine (AZT) in alteration of TELOMERASE ACTIVITY and Bcl-2 concentration in HCC.Methods: Healthy adult male Wistar rats (n=100) were randomly divided into 4 groups (A, B, C, and D). Group A contained 25 healthy rats and was considered as the control group. Liver preneoplastic lesions were induced in remaining animals (n=75) using Solt-Farber resistant hepatocyte protocol. These animals were randomly allocated in groups B, C and D. Group B was negative control (untreated), groups C and D were treated by intraperitoneal injection (IP) of Pt-AZT (0.9 mg/kg/day) and AZT (0.3 mg/kg/day), respectively for 14 days. After the treatment period, TELOMERASE ACTIVITY and Bcl-2 concentration were determined in the rats’ liver.Results: No HCC was developed in group A, but tumors were present in all other groups. TELOMERASE ACTIVITY and Bcl-2 concentration were significantly lower in group C compared to groups B (0.159±0.06 vs.0.577±0.116 IU/L, p<0.001, respectively and 0.931±0.388 vs.3.94±0.74 ng/ml, p<0.001, respectively). Similar results were observed in comparison with group D (0.331±0.06 vs.0.577±0.116 IU/L, p<0.001, respectively and 0.931±0.388 vs.2.94±0.594 ng/ml, respectively). There was a significant negative correlation between TELOMERASE ACTIVITY and Bcl-2 concentration only in untreated cancer group (p=0.034).Conclusion: In this study, higher anticancer activity of Pt-AZT in comparison to AZT was demonstrated. It effectively inhibits the growth of liver tumor in rats through extending apoptosis.

Cites

COMPARISON BETWEEN PLATINUM-AZIDOTHYMIDINE AND AZIDOTHYMIDINE EFFECTS ON BCL-2 AND TELOMERASE GENE EXPRESSION IN RATS WITH HEPATOCELLULAR CARCINOMA

References

Cite

APA: Copy

SABOKROUH, ABDOLREZA, GOODARZI, MOHAMAD TAGHI, VAISI RAYGANI, ASAD, KHATAMI, SHOHREH, & TAGHIZADEH JAHED, MASOUD. (2014). EFFECTS OF TREATMENT WITH PLATINUM AZIDOTHYMIDINE AND AZIDOTHYMIDINE ON TELOMERASE ACTIVITY AND BCL-2 CONCENTRATION IN HEPATOCELLULAR CARCINOMA- INDUCED RATS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 6(4), 200-209. SID. https://sid.ir/paper/313853/en

Vancouver: Copy

SABOKROUH ABDOLREZA, GOODARZI MOHAMAD TAGHI, VAISI RAYGANI ASAD, KHATAMI SHOHREH, TAGHIZADEH JAHED MASOUD. EFFECTS OF TREATMENT WITH PLATINUM AZIDOTHYMIDINE AND AZIDOTHYMIDINE ON TELOMERASE ACTIVITY AND BCL-2 CONCENTRATION IN HEPATOCELLULAR CARCINOMA- INDUCED RATS. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2014;6(4):200-209. Available from: https://sid.ir/paper/313853/en

IEEE: Copy

ABDOLREZA SABOKROUH, MOHAMAD TAGHI GOODARZI, ASAD VAISI RAYGANI, SHOHREH KHATAMI, and MASOUD TAGHIZADEH JAHED, “EFFECTS OF TREATMENT WITH PLATINUM AZIDOTHYMIDINE AND AZIDOTHYMIDINE ON TELOMERASE ACTIVITY AND BCL-2 CONCENTRATION IN HEPATOCELLULAR CARCINOMA- INDUCED RATS,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 6, no. 4, pp. 200–209, 2014, [Online]. Available: https://sid.ir/paper/313853/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops